Browsing by Author "Nagahawatte, A."

Browsing by Author "Nagahawatte, A."

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  • Analysis of Dengue Serotype 4 in Sri Lanka During the 2012–2013 Dengue Epidemic 
    Uehara, Anna; Tissera, H.A.; Bodinayake, C.K.; Amarasinghe, A.; Nagahawatte, A.; Tillekeratne, L.G.; Jie Cui; Reller, Megan E.; Palihawadana, P.; Gunasena, S.; De Silva, A.D.; Wilder-Smith, A.; Gubler, Duane J.; Woods, Christopher W.; Sessions, October M. (The American journal of tropical medicine and hygiene, 2017-07-12)
    The four serotypes of dengue virus (DENV-1, -2, -3, and -4) have had a rapidly expanding geographic range and are now endemic in over 100 tropical and subtropical countries. Sri Lanka has experienced periodic dengue outbreaks ...
  • The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka 
    Napagoda, M.; Gerstmeier, J.; Butschek, H.; De Zoysa, S.; Pace, Simona; Lorenz, Sybille; Qader, Mallique; Witharana, S.; Nagahawatte, A.; Wijayaratne, G.; Svatoš, Aleš; Jayasinghe, L.; Koeberle, A.; Werz, Oliver (MDPI, 2020-04-20)
    Traditional folk medicine in Sri Lanka is mostly based on plants and plant-derived products, however, many of these medicinal plant species are scientifically unexplored. Here, we evaluated the anti-inflammatory and ...
  • Antibiotic Overuse for Acute Respiratory Tract Infections in Sri Lanka: a Qualitative Study of Outpatients and their Physicians 
    Tillekeratne, L.G.; Bodinayake, C.K.; Dabrera, T.; Nagahawatte, A.; Arachchi, W.K.; Sooriyaarachchi, A.; Stewart, Kearsley; Watt, Melissa; Ostbye, T.; Woods, Christopher W. (BioMed Central Ltd., 2017-03-16)
    Background: Acute respiratory tract infections (ARTIs) are a common reason for antibiotic overuse worldwide. We previously showed that over 80% of outpatients presenting to a tertiary care hospital in Sri Lanka with ...
  • Barriers to Implementing Antimicrobial Stewardship Programs in Three Low- and Middle-income Country Tertiary Care Settings: Findings from a Multi-site Qualitative Study 
    Rolfe Jr, Robert; Kwobah, Charles; Muro, Florida; Ruwanpathirana, A.; Lyamuya, Furaha S.; Bodinayake, C.K.; Nagahawatte, A.; Piyasiri, B.; Tianchen Sheng; Bollinger, J.; Chi Zhang; Truls Ostbye; Ali, Shamim; Drew, R.; Kussin, P.; Anderson, Deverick J.; Woods, Christopher W.; Watt, Melissa H.; Mmbaga, Blandina T.; Tillekeratne, L.G. (Springer Nature, 2021-03-25)
    Background: Antimicrobial resistance has been named as one of the top ten threats to public health in the world. Hospital-based antimicrobial stewardship programs (ASPs) can help reduce antimicrobial resistance. The purpose ...
  • Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka 
    Shapiro, David; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Kurukulasooriya, R.; Hsiang, Jeremy; Nicholson, B.P.; De Silva, A.D.; Ostbye, T.; Reller, Megan E.; Woods, Christopher W.; Tillekeratne, L.G. (The American journal of tropical medicine and hygiene, 2017-07-12)
    In tropical and subtropical settings, the epidemiology of viral acute respiratory tract infections varies widely between countries. We determined the etiology, seasonality, and clinical presentation of viral acute respiratory ...
  • Chikungunya as a Cause of Acute Febrile Illness in Southern Sri Lanka 
    Reller, Megan E.; Akoroda, Ufuoma; Nagahawatte, A.; Devasiri, V.; Strouse, John J.; Chua, Robert; Yan'an Hou; Chow, Angelia; Sessions, October M.; Ostbye, T.; Gubler, Duane J.; Woods, Christopher W.; Bodinayake, C.K. (Public Library of Science (PLOS) , 2013-12-02)
    Background: Chikungunya virus (CHIKV) re-emerged in Sri Lanka in late 2006 after a 40-year hiatus. We sought to identify and characterize acute chikungunya infection (CHIK) in patients presenting with acute undifferentiated ...
  • Colonization with Multidrug-resistant Enterobacteriaceae Among Infants: an Observational Study in Southern Sri Lanka 
    Meredith, Hannah R.; Kularathna, S.; Nagaro, Kristin; Nagahawatte, A.; Bodinayake, C.K.; Kurukulasooriya, R.; Wijesingha, N.; Harden, Lyndy B.; Piyasiri, B.; Hammouda, Amr; Wiegmann, Brian M.; Nicholson, B.P.; Joyce, Maria; Woods, Christopher W.; Van Vliet, Arnoud H. M.; Thakur, Siddhartha; Tillekeratne, L.G. (Springer Nature, 2021-04-30)
    Background The timing of and risk factors for intestinal colonization with multidrug-resistant Enterobacteriaceae (MDRE) are still poorly understood in areas with high MDRE carriage. We determined the prevalence, timing, ...
  • Comprehensive Diagnostic Testing Identifies Diverse Aetiologies of Acute Febrile Illness Among Hospitalised Children and Adults in Sri Lanka: a Prospective Cohort Study 
    Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Arachichi, W.K.; Kurukulasooriya, R.; Tianchen Sheng; Nicholson, B.P.; Ostbye, T.; Reller, Megan; Woods, Christopher W.; Tillekeratne, L.G. (BMJ Public Health, 2023-07-31)
    Introduction Acute febrile illness (AFI) is a common cause of hospital admissions in tropical settings. Identifying AFI aetiology is essential for guiding clinicians’ diagnoses and developing diagnostic and management ...
  • Diagnosis of Tuberculous Lymphadenitis Combining Cytomorphology, Microbiology and Molecular Techniques - a Study from Sri Lanka 
    Mudduwa, L.K.B.; Nagahawatte, A. (Indian Journal of Pathology and Microbiology, 2008-04)
    Background: Fine needle aspiration is a simple technique to obtain material for early diagnosis of tuberculous lymphadenitis. Objective: To assess the value of fine needle aspiration cytology (FNAC) in the diagnosis of ...
  • Direct and Indirect Costs for Hospitalized Patients with Dengue in Southern Sri Lanka 
    Weerasinghe, N.P.; Bodinayake, C.K.; Wijayaratne, W.M.D.G.B.; Devasiri, I.V.; Dahanayake, N.J.; Kurukulasooriya, M.R.P.; Premamali, M.; Sheng, T.; Nicholson, B.P.; Ubeysekera, H.A.; De Silva, A.D.; Østbye, T.; Woods, C.W.; Tillekeratne, L.G.; Nagahawatte, A. (BioMed Central, 2022-05-16)
    Background The Southern Province of Sri Lanka is endemic with dengue, with frequent outbreaks and occurrence of severe disease. However, the economic burden of dengue is poorly quantified. Therefore, we conducted a cost ...
  • Electronic Clinical Decision Support Tools: Strategies to Improve the Management of Lower Respiratory Tract Infections in Low-Resource Settings 
    Tillekeratne, L.G.; Soyza, W.D.; Iglesias-Ussel, M.D.; Olague, S.; Palangasinghe, D.; Nagahawatte, A.; Wickramatunga, T.; Gamage, J.; Kurukulasooriya, R.; Premamali, M.; Ngocho, J.; Obale, A.; Sanborn, K.; Gallis, J.; Woods, C.W.; Naggie, S.W.; Ostbye, T.; Chakraborty, H.; Laber, E.; Myers, Evan R.; Watt, M.; Bodinayake, C.K. (American Society of Tropical Medicine and Hygiene, 2024-10-08)
    Lower respiratory tract infection (LRTI) is a common reason for hospitalization and antibacterial use globally. There is considerable overlap in the clinical presentation of bacterial and viral LRTIs. Low- or middle-income ...
  • Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka 
    Bodinayake, C.K.; Tillekeratne, L.G.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Strouse, John J.; Sessions, October M.; Kurukulasooriya, R.; Uehara, Anna; Howe, Shiqin; Xin Mei Ong; Tan, Sharon; Chow, Angelia; Tummalapalli, P.; De Silva, A.D.; Ostbye, T.; Woods, Christopher W.; Gubler, Duane J.; Reller, Megan E. (Public Library of Science (PLOS), 2016-10-06)
    Background Dengue is a frequent cause of acute febrile illness with an expanding global distribution. Since the 1960s, dengue in Sri Lanka has been documented primarily along the heavily urbanized western coast with ...
  • Epidemiological and clinical characteristics of dengue during epidemic and nonepidemic periods in southern Sri Lanka- lessons learned from 2007 and 2012-2013 
    Bodinavake, C.K.; Tillekeratne, L.G.; Nagahawatte, A.; Devasiri, I.V.; KodikaraArachchi, W.; Ostbye, T.; Gubler, D.J.; Woods, C.W.; Reller, M.E. (Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka, 2014-07)
    We evaluated epidemiological, clinical characteristics of dengue, comparing two similar studies performed at Teaching Hospital Karapitiya (THK) Galle during outbreak (2012-2013) and without outbreak (2007). Two cross-sectional ...
  • Evaluation of the WHO 2009 Classification for Diagnosis of Acute Dengue in a Large Cohort of Adults and Children in Sri Lanka During a Dengue-1 Epidemic 
    Bodinayake, C.K.; Tillekeratne, L.G.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Strouse, John J.; Sessions, October M.; Kurukulasooriya, R.; Uehara, Anna; Howe, Shiqin; Xin Mei Ong; Tan, Sharon; Chow, Angelia; Tummalapalli, P.; De Silva, A.D.; Ostbye, T.; Woods, Christopher W.; Gubler, Duane J.; Reller, Megan E. (Public Library of Science (PLOS), 2018-02-09)
    Background Dengue is a leading cause of fever and mimics other acute febrile illnesses (AFI). In 2009, the World Health Organization (WHO) revised criteria for clinical diagnosis of dengue. Methodology/Principal ...
  • Extended-spectrum ß-Lactamase-producing Enterobacteriaceae as a Common Cause of Urinary Tract Infections in Sri Lanka 
    Tillekeratne, L.G.; Vidanagama, D.; Tippalagama, R.; Lewkebandara, R.; Joyce, Maria; Nicholson, B.P.; Nagahawatte, A.; Bodinayake, C.K.; De Silva, A.D.; Woods, Christopher W. (Infect Chemother, 2016-09-23)
    Background: Extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-PE) are increasingly reported as pathogens in urinary tract infections (UTIs). However, in Sri Lanka, the clinical and molecular epidemiology ...
  • Geospatial Analysis of Dengue Emergence in Rural Areas in the Southern Province of Sri Lanka 
    Mutucumarana, C.P.; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Kurukulasooriya, R.; Anuradha, T.; De Silva, A.D.; Janko, Mark M.; Ostbye, T.; Gubler, Duane J.; Woods, Christopher W.; Reller, Megan E.; Tillekeratne, L.G.; Lantos, Paul M. (Oxford University Press, 2020-06-01)
    Background: Dengue is a major cause of acute febrile illness in Sri Lanka. Dengue has historically been considered an urban disease. In 2012–2013, we documented that acute dengue was surprisingly associated with self- reported ...
  • The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood 
    Tsalik, Ephraim L.; Fiorino, Cassandra; Aqeel, Ammara; Liu, Yiling; Henao, Ricardo; Ko, Emily R.; Burke, Thomas W.; Reller, Megan E.; Bodinayake, C.K.; Nagahawatte, A.; Arachchi, W.K.; Devasiri, V.; Kurukulasooriya, R.; McClain, Micah T.; Woods, Christopher W.; Ginsburg, G.S.; Tillekeratne, L.G.; Schughart, Klaus (Frontiers Media SA , 2021-10-27)
    Viruses cause a wide spectrum of clinical disease, the majority being acute respiratory infections (ARI). In most cases, ARI symptoms are similar for different viruses although severity can be variable. The objective of ...
  • Influenza Vaccination Implementation in Sri Lanka: A Cost-Effectiveness Analysis 
    Neighbors, Coralei E.; Myers, Evan R.; Weerasinghe, N.P.; Wijayaratne, W.M.D.G.B.; Bodinayake, C.K.; Nagahawatte, A.; Tillekeratne, L.G.; Woods, Christopher W. (Vaccine, 2023-05-03)
    nfluenza causes an estimated 3 to 5 million cases of severe illness annually, along with substantial morbidity and mortality, particularly in low- and middle-income countries (LMICs). Currently, Sri Lanka has no influenza ...
  • Knowledge, Perceptions, and Attitudes Regarding Antibiotic Use for Lower Respiratory Tract Infections: Insights from Patients in Sri Lanka. 
    Van Melle, David T.; Asbroek, Guus Ten; Rolfe, R.; Vanderburg, Sky; Abeysinghe, Y. W.; Halloluwa, C.; Zhang, Helen L.; Ostbye, T.; Kurukulasooriya, R.; Tianchen Sheng; Kanchana, S.; Wijayaratne, W.M.D.G.B.; Bodinayake, C.K.; Nagahawatte, A.; Watt, Melissa H.; Woods, Christopher W.; De Silva, P.V.; Tillekeratne, L.G. (American Society of Tropical Medicine and Hygiene, 2021-09-27)
    Antibiotic resistance is an emerging global public health threat. One of the main drivers of this threat is the inappropriate use of antibiotics. In Sri Lanka, antibiotic consumption is increasing, but little is known ...
  • Leptospirosis as Frequent Cause of Acute Febrile Illness in Southern Sri Lanka 
    Reller, Megan E.; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Strouse, John J.; Flom, Judith E.; Dumler, J. Stephen; Woods, Christopher W. (Centres for Disease Control and Prevention, United States, 2011-09-09)
    To determine the proportion of fevers caused by leptospirosis, we obtained serum specimens and epidemiologic and clinical data from patients in Galle, Sri Lanka, March-October 2007. Immunoglobulin M ELISA was performed on ...

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