Effect of Melothria Maderaspatana on Carbon Tetrachloride-induced Changes in rat Hepatic Microsomal Drug-metabolizing Enzyme Activity

dc.contributor.author	Jayatilaka, K.A.P.W.
dc.contributor.author	Thabrew, M.I.
dc.contributor.author	Perera, D.J.
dc.date.accessioned	2023-10-05T07:39:53Z
dc.date.available	2023-10-05T07:39:53Z
dc.date.issued	1990-08-01
dc.identifier.citation	Jayatilaka KA, Thabrew MI, Perera DJ. Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity. J Ethnopharmacol. 1990 Aug;30(1):97-105. doi: 10.1016/0378-8741(90)90020-t. PMID: 2214827.	en_US
dc.identifier.uri	http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/14977
dc.description.abstract	Treatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or after CCl4 administration in rats markedly decreased CCl4-mediated reductions in aniline hydroxylase and p-aminopyrine N-demethylase activities. Phenobarbital-induced sleeping time in rats and kinetic enzyme studies showed that the effect of the plant was neither due to an induction of the drug metabolizing enzymes nor due to an alteration in the Km values of the enzymes.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.subject	Drug Discovery	en_US
dc.subject	pharmacology	en_US
dc.title	Effect of Melothria Maderaspatana on Carbon Tetrachloride-induced Changes in rat Hepatic Microsomal Drug-metabolizing Enzyme Activity	en_US
dc.type	Article	en_US