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Department of Biochemistry: Recent submissions

Now showing items 81-100 of 164

Exploring the Plant Kingdom for the Development of Novel Sunscreen Formulations

Napagoda, M.; Witharana, S.; Jayasinghe, L. (International Natural Product Sciences Taskforce (INPST), 2019-01-26)

Exposure to solar radiation, particularly to its ultraviolet (UV) components has a variety of harmful effects on human skin, ranging from mild inflammatory effects to as severe as causing several types of cancers. Thus, ...
In vitro Antiurolithiatic Potential in Asparagus falcatus L., A Folklore Medicinal Plant in Sri Lanka

Napagoda, M.; Madhumadhavi, N.; Vimukthi, K.; Malkanthi, S.; Abayawardana, K. (Journal of PharmaSciTech, 2020-09-01)

Urolithiasis is the condition where urinary calculi are formed in the urinary tract and is identified as one of the most prevalent diseases throughout the globe. However, the treatment approaches employed in modern medicine ...
In vitro Evaluation of UV-filtering and Anti-tyrosinase Potential in Selected Medicinal Plants in Sri Lanka for the Development of Herbal Cosmetics

Napagoda, M.; Kumari, M.; Samaranayake, U. (Chirantan Rasayan Sanstha, 2021-12-23)

This study was conducted to evaluate the in vitro Ultra-Violet(UV) filtering and anti-tyrosinase potential in several medicinal plants. The methanolic extract of Tagetes erecta has displayed a sun protection factor (SPF) ...
In-Vitro Anti-inflammatory Potential in Hibiscus Furcatus Willd

Napagoda, M.; Malkanthi, B.M.A.S.; Abayawardana, S.A.K.; Qader, M.M.; Jayasinghe, L. (ResearchGate, 2015-12)

Hibiscus furcatus Willd.(Malvaceae) is a semi-shrubby perennial, extensively utilized in Sri Lankan traditional medicine for the treatment of inflammatory conditions, skin diseases and related disorders. However, neither ...
Inhibition of 5-lipoxygenase as Anti-inflammatory mode of action of Plectranthus Zeylanicus Benth and Chemical Characterization of Ingredients by a mass Spectrometric Approach

Napagoda, M.; Gerstmeier, J.; Wesely, Sandra; Popella, Sven; Lorenz, Sybille; Scheubert, Kerstin; Svatoš, Aleš; Werz, Oliver (Elsevier, 2014-02-03)

Ethnopharmacological relevance: The perennial herb Plectranthus zeylanicus Benth is extensively used in traditional medicine in Sri Lanka and South India for treating inflammatory conditions, but pharmacological features ...
Introduction to Nanotechnology

Napagoda, M.; Jayathunga, D.; Witharana, S. (Springer Nature, 2022-12-15)

In principle, nanomaterials are materials with at least one dimension of 100 nm or less. Although nanotechnology; the science of the nanoscale, has emerged as a scientific discipline in the late twentieth century, human ...
Lipophilic Extracts of Leucas zeylanica, a Multi-purpose Medicinal Plant in the Tropics, Inhibit key Enzymes Involved in Inflammation and Gout

Napagoda, M.; Gerstmeier, J.; Butschek, H.; Lorenz, Sybille; Kanatiwela, Dinusha; Qader, Mallique; Nagahawatte, A.; De Zoysa, S.; Witharana, G.B.; Svatoš, Aleš; Jayasinghe, L.; Koeberle, A.; Werz, Oliver (Elsevier, 2018-10-05)

Ethnopharmacological relevance: Leucas zeylanica (L.) W.T. Aiton is a popular, multi-purpose medicinal plant in Sri Lanka but the pharmacological potential and the chemical profile have not been systematically investigated ...
Metabolomics for Natural Products: Fast screening and Discovery

Napagoda, M. (2014-09-16)
Munronia Pinnata (Wall.) Theob.: unveiling Phytochemistry and Dual Inhibition of 5-lipoxygenase and Microsomal Prostaglandin E2 Synthase (mPGES)-1

Napagoda, M.; Gerstmeier, J.; Koeberle, A.; Wesely, Sandra; Popella, Sven; Lorenz, Sybille; Scheubert, Kerstin; Böcker, Sebastian; Svatoš, Aleš; Werz, Oliver (Elsevier, 2014-02-03)

Ethnopharmacological relevance: Preparations from Munronia pinnata (Wall.) Theob. are extensively used in traditional medicine in Sri Lanka for the treatment of inflammatory conditions. However, neither the pharmacological ...
Nanomaterials for Wound Healing and Tissue Regeneration

Napagoda, M.; Madhushanthi, P.; Witharana, S. (Springer Nature, 2022-12-15)

Being the largest organ and the protective shield of the human body, the skin is highly vulnerable to potential injuries. A cascade of biological events initiates after the injury to regenerate and repair the damaged tissue ...
Photoprotective Potential in some Medicinal Plants used to Treat Skin Diseases in Sri Lanka

Napagoda, M.; Malkanthi, B.M.A.S.; Abayawardana, S.A.K.; Qader, M.M.; Jayasinghe, L. (BMC Complement Altern, 2016-11-24)

Background: The constant exposure to solar ultraviolet radiation (UV) has a variety of harmful effects on human health. Although synthetic sunscreen products have been introduced as a preventive/therapeutic strategy, with ...
Plant-based Nanomaterials and their Antimicrobial Activity

Napagoda, M.; Madhushanthi, P.; Wanigasekara, D.; Witharana, S. (CRC Press, 2022)

The emergence of microbial resistance to currently deployed antimicrobial agents has resulted considerable mortality and morbidity worldwide thus demanding the development of novel antimicrobial substances with diverse ...
Plectranthus zeylanicus: A Rich Source of Secondary Metabolites with Antimicrobial, Disinfectant and Anti-Inflammatory Activities

Napagoda, M.; Gerstmeier, J.; Butschek, H.; Lorenz, Sybille; De Zoysa, S.; Qader, Mallique; Nagahawatte, A.; Wijayaratne, W.M.D.G.B.; Schneider, B.; Svatoš, Aleš; Jayasinghe, L.; Koeberle, Andreas; Werz, Oliver (Pharmaceuticals, 2022-03-31)

Plectranthus zeylanicus Benth is used in Sri Lankan folk medicine as a remedy for inflammatory conditions and microbial infections. Our previous investigations revealed potent 5-lipoxygenase (5-LO) inhibitory activity in ...
Popularity and Usage of Different Skincare agents among the Inhabitants of Galle District in Southern Province, Sri Lanka

Napagoda, M.; Dahanayake, B.; Lankika, S.; Dahanayake, G.; Wannakukorala, M.; Manampery, R.; Jayasekera, N.; Tiranagama, T.; Kumari, D. (Ruhuna Journal of Science, 2020-09-18)

Cosmetics could be considered as one of the essential commodities in modern society, and the use of skincare agents has become a common practice in both men and women in Sri Lanka. Therefore, the present study was conducted ...
Self-assembled Renewable Nano-sized Pentacyclic Triterpenoid Maslinic Acids in Aqueous Medium for Anti-leukemic, Antibacterial and Biocompatibility Studies: an Insight into Targeted Proteins-compound Interactions Based Mechanistic Pathway Prediction Through Molecular Docking

Hasan, S.K. Nurul; Banerjee, J.; Patra, S.; Kar, Sukhendu; Das, Sayan; Samanta, S.; Wanigasekara, D.; Pavithra, U.; wijesekare, K.; Napagoda, M.; Giri, Biplab; Dash, S. Kumar; Bag, B.G. (Elsevier, 2023-08-01)

Maslinic acid is a naturally occurring dihydroxy, mono-carboxy bioactive triterpenoid. Its bulky structure was the main hindrance in the path of biological activity. Sodium and potassium salts of nano-sized triterpenoid ...
Study of antibacterial activity in biogenic silver nanoparticles prepared from Eichhornia crassipes(Mart.) Solms

Kirisenage, P.; Wijayaratne, W.M.D.G.B.; Witharana, S.; Napagoda, M. (American Chemical Society, 2022-03)

The increase of antibiotic resistance in bacteria has become a major problem. Therefore, alternative antimicrobial agents are required to address this problem. Among all the metals silver has shown to have a higher ...
Traditional Uses of Medicinal Plants in Polonnaruwa District in North Central Province of Sri Lanka

Napagoda, M.; Sundarapperuma, T.; Fonseka, D.; Amarasiri, S.; Gunaratna, P. (Hindawi, 2019-05-28)

Sri Lanka harbors over 3000 plant species, and most of these plants have been of immense importance in the traditional systems of medicine in the country. Although there is a rich reserve of indigenous knowledge on medicinal ...
Development of Herbal Sunscreen Formulations from the Leaves of Sri Lankan Medicinal Plants, Hibiscus Furcatus wild. and Olax Zeylanica Linn

Liyanaarachchi, C.E.; Napagoda, M.; Malkanthi, S.; Abayawardana, K.; Witharana, S.; Jayasinghe, L. (Journal of Science, 2022-12-31)

Excessive exposure to ultraviolet (UV) radiation in the sunlight has many deleterious consequences on human skin. In order to alleviate these harmful effects, sunscreen formulations are widely used. Although most of these ...
Determination of Tolerance Limits of Dimethyl Sulfoxide (DMSO) on Selected Bacterial Strains for the Antimicrobial Assays of Natural Products

Wanigasekara, D.; Madhushanthi, P.; Liyanaarachchi, C.; Wijayaratne, G.; Napagoda, M. (University of Sri Jayewardenepura, Sri Lanka, 2021-09-06)

Dimethyl sulfoxide (DMSO) is extensively used as a solvent in natural product chemistry to dissolve plant extracts. Although it serves as a universal solvent for many fields of science, the toxicity of certain concentrations ...
Determination of Photoprotective Potential in Sunscreen Formulations with Different Concentrations of Olax zeylanica (Mella) Extract

Liyanaarachchi, C.E.; Napagoda, M.; Malkanthi, S.; Abayawardana, K.; Witharana, S.; Jayasinghe, L. (Research Symposium on Pure and Applied Sciences, 2018 Faculty of Science, University of Kelaniya, Sri Lanka, 2018-10-26)

The ultra-violet (UV) component of the solar radiation can cause various deleterious effects on the human skin. The occurrence of wide range of dermatological diseases are correlated with the excessive exposure to UV ...

Now showing items 81-100 of 164

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