22nd Academic Session -2025 http://ir.lib.ruh.ac.lk/handle/iruor/19529 2026-04-28T04:23:00Z 2026-04-28T04:23:00Z Invited Oration Pharma-nature Fusion: Integrated Approaches for Effective Pain Control and Relief Wasana, P.W.D. http://ir.lib.ruh.ac.lk/handle/iruor/20828 2026-04-09T06:41:57Z 2025-06-04T00:00:00Z Invited Oration Pharma-nature Fusion: Integrated Approaches for Effective Pain Control and Relief Wasana, P.W.D. Pain management poses a significant healthcare challenge, prompting exploration into innovative strategies. Our work embodies a fusion of pharmaceutical and natural approaches to enhance pain relief using curcumin, a natural polyphenolic compound. Through synergistic drug combinations (curcumin-metformin and curcumin-piperine), nanoformulations (curcumin-metformin-coloaded chitosan/alginate nanoparticles), and prodrug development (curcumin diglutaric acid, curcumin diethyl diglutarate, and curcumin diethyl γ-aminobutyrate), we aimed to fortify curcumin's efficacy against diverse pain types. Findings demonstrated enhanced analgesic effects, improved pharmacokinetic profiles, and promising safety profiles, laying the foundation for advanced pain management solutions integrating pharmaceutical and natural elements. 2025-06-04T00:00:00Z Cover page http://ir.lib.ruh.ac.lk/handle/iruor/19821 2025-07-16T09:17:48Z 2025-06-04T00:00:00Z Cover page 2025-06-04T00:00:00Z Detils http://ir.lib.ruh.ac.lk/handle/iruor/19820 2025-07-16T09:16:22Z 2025-06-04T00:00:00Z Detils 2025-06-04T00:00:00Z Organizing Committee http://ir.lib.ruh.ac.lk/handle/iruor/19819 2025-07-16T09:11:08Z 2025-06-04T00:00:00Z Organizing Committee 2025-06-04T00:00:00Z