http://ir.lib.ruh.ac.lk/handle/iruor/7398 2026-04-27T11:14:02Z 2026-04-27T11:14:02Z Pratheepan, G.J. Bodinayake, C.K. http://ir.lib.ruh.ac.lk/handle/iruor/19225 2025-03-03T08:47:24Z 2009-07-29T00:00:00Z

A Case of Cerebral Malaria: are we Alert to Detect? Pratheepan, G.J.; Bodinayake, C.K. Malaria is an important treatable cause of fever. Cerebral malaria caused by Plasmodium falciparum causes multisystem involvement leading to death. Though malaria was a common illness in Sri Lanka years back, the incidence is now very low. Total of 196 cases of malaria and 8 cases of cerebral malaria were reported in 2007 1. We report a case of cerebral malaria from Galle with many of its complications

2009-07-29T00:00:00Z Reller, Megan E. Bodinayake, C.K. Nagahawatte, A. Devasiri, V. Arachchi, W.K. Strouse, John J. Flom, Judith E. Dumler, J. Stephen Woods, Christopher W. http://ir.lib.ruh.ac.lk/handle/iruor/19224 2025-03-03T08:37:27Z 2011-09-09T00:00:00Z

Leptospirosis as Frequent Cause of Acute Febrile Illness in Southern Sri Lanka Reller, Megan E.; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Strouse, John J.; Flom, Judith E.; Dumler, J. Stephen; Woods, Christopher W. To determine the proportion of fevers caused by leptospirosis, we obtained serum specimens and epidemiologic and clinical data from patients in Galle, Sri Lanka, March-October 2007. Immunoglobulin M ELISA was performed on paired serum specimens to diagnose acute (seroconversion or 4-fold titer rise) or past (titer without rise) leptospirosis and seroprevalence (acute). We compared (individually) the diagnostic yield of acute-phase specimens and clinical impression with paired specimens for acute leptospirosis. Of 889 patients with paired specimens, 120 had acute leptosoirosis and 241 had past leptospirosis. The sensitivity and specificity of acute-phase serum specimens were 17.5% (95% confidence interval [CI] 11.2%-25.5%) and 69.2% (95% CI 65.5%-72.7%), respectively, and of clinical impression 22.9% (95% CI 15.4%-32.0%) and 91.7% (95% CI 89.2%-93.8%), respectively. For identifying acute leptospirosis, clinical impression is insensitive, and immunoglobulin M results are more insensitive and costly. Rapid, pathogen-based tests for early diagnosis are needed.

2011-09-09T00:00:00Z Egodage, U.K. Dharmarathne, C. Mohideen, M.S. Dahanayake, M.U. Bodinayake, C.K. http://ir.lib.ruh.ac.lk/handle/iruor/19196 2025-03-03T04:21:55Z 2015-11-01T00:00:00Z

A Case of Infective Endocarditis Caused by Salmonella Paratyphi A Egodage, U.K.; Dharmarathne, C.; Mohideen, M.S.; Dahanayake, M.U.; Bodinayake, C.K. Introduction: Endocarditis is a rare complication of salmonellosis. The most frequently observed species is Salmonella typhi[1]. Endocarditis caused by Salmonella paratyphi is extremely rare with only few previous cases documented in the medical literature[2-7]. We report a case of endocarditis caused by Salmonella paratyphi A in an otherwise healthy young patient.

2015-11-01T00:00:00Z Reller, Megan E. Bodinayake, C.K. Nagahawatte, A. Devasiri, V. Arachchi, W.K. Strouse, John J. Broadwater, Anne Ostbye, T. De Silva, A. Woods, Christopher W. http://ir.lib.ruh.ac.lk/handle/iruor/19195 2025-03-02T10:21:41Z 2012-02-02T00:00:00Z

Unsuspected Dengue and Acute Febrile Illness in Rural and Semi-Urban Southern Sri Lanka Reller, Megan E.; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Strouse, John J.; Broadwater, Anne; Ostbye, T.; De Silva, A.; Woods, Christopher W. Dengue virus (DENV), a globally emerging cause of undifferentiated fever, has been documented in the heavily urbanized western coast of Sri Lanka since the 1960s. New areas of Sri Lanka are now being affected, and the reported number and severity of cases have increased. To study emerging DENV in southern Sri Lanka, we obtained epidemiologic and clinical data and acute- and convalescent-phase serum samples from patients >2 years old with febrile illness. We tested paired serum samples for DENV IgG and IgM and serotyped virus by using isolation and reverse transcription PCR. We identified acute DENV infection (serotypes 2, 3, and 4) in 54 (6.3%) of 859 patients. Only 14% of patients had clinically suspected dengue; however, 54% had serologically confirmed acute or past DENV infection. DENV is a major and largely unrecognized cause of fever in southern Sri Lanka, especially in young adults.

2012-02-02T00:00:00Z