dc.contributor.author |
Fadilah, Nurul Q. |
|
dc.contributor.author |
Jittmittraphap, Akanitt |
|
dc.contributor.author |
Leaungwutiwong, Pornsawan |
|
dc.contributor.author |
Pripdeevech, Patcharee |
|
dc.contributor.author |
Dhanushka, Darshana |
|
dc.contributor.author |
Mahidol, Chulabhorn |
|
dc.contributor.author |
Chulabhorn, Somsak |
|
dc.contributor.author |
Kittakoop, Prasat |
|
dc.date.accessioned |
2023-01-10T04:25:18Z |
|
dc.date.available |
2023-01-10T04:25:18Z |
|
dc.date.issued |
2022 |
|
dc.identifier.citation |
Fadilah, N. Q., Jittmittraphap, A., Leaungwutiwong, P., Pripdeevech, P., Dhanushka, D., Mahidol, C., ... & Kittakoop, P. (2022). Virucidal Activity of Essential Oils From Citrus x aurantium L. Against Influenza A Virus H 1 N 1: Limonene as a Potential Household Disinfectant Against Virus. Natural Product Communications, 17(1), 1934578X211072713. |
en_US |
dc.identifier.uri |
http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/10123 |
|
dc.description.abstract |
This work explored the compositions of a crude extract of peels of Citrus x aurantium using a gas chromatography-mass spectrometry
(GC-MS) technique. The crude extract of peels of C. × aurantium was analyzed by GC-MS revealing the presence of limonene as the
major compound, accounting for 93.7% of the total. Virucidal activity of the oil of C. x aurantium peels against influenza A virus
H1N1 was evaluated by the ASTM E1053-20 method. Moreover, the virucidal activity was also investigated of D-limonene, the
major terpene in essential oils of C. x aurantium, and its enantiomer L-limonene. The essential oil of the C. x aurantium peels produced
a log reduction of 1.9 to 2.0, accounting for 99% reduction of the virus, while D- and L-limonene exhibited virucidal activity with a
log reduction of 3.70 to 4.32 at concentrations of 125 and 250.0 µg/mL, thus reducing the virus by 99.99%. Previous work found
that D-limonene exhibited antiviral activity against herpes simplex virus, but L-limonene, an enantiomer of D-limonene, has never
been reported for antiviral activity. This work demonstrates the antiviral activity of L-limonene for the first time. Moreover, this work
suggests that concentrations of 0.0125% to 0.025% of either D- or L-limonene can possibly be used as a disinfectant against viruses,
probably in the form of essential oil sprays, which may be useful disinfectants against the airborne transmission of viruses, such as
influenza and COVID-19. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
SAGE Publications |
en_US |
dc.subject |
bitter orange |
en_US |
dc.subject |
citrus x aurantium |
en_US |
dc.subject |
essential oils |
en_US |
dc.subject |
antiviral activity |
en_US |
dc.subject |
virucidal activity |
en_US |
dc.subject |
limonene |
en_US |
dc.subject |
disinfectant |
en_US |
dc.subject |
GC-MS |
en_US |
dc.title |
Virucidal Activity of Essential Oils From Citrus x aurantium L. Against Influenza A Virus H1N1: Limonene as a Potential Household Disinfectant Against Virus |
en_US |
dc.type |
Article |
en_US |