Abstract:
Actinidia macrosperma which belongs to the genus Actinidia of the
Actinidiaceae family is a non-commercial type kiwifruit. This plant has its
reputation to treat various diseases within Chinese traditional medicine.
Recent studies have shown that the different parts of A. macrosperma plant
exhibit various biological activities. In this study, the potential application
of antihypertensive activity of flavonoid rich defatted crude extracts
obtained from A. macrosperma fruit was determined by in vitro assay using
fluorescence based biochemical reaction. The different extracts obtained
from A. macrosperma fruit were performed for the ACE inhibitory activity
and results showed that they are moderately effective ACE inhibitors.
Among the results obtained in the present study, it should be highlighted
that the activity observed for the extract from 70% acetone by steeping
method exhibited quite promising ACE inhibitory activity (lowest IC50
values), as compared to the other solvent extracts tested. Based on the
experimental results, kiwifruit has potential use as a cardiovascular
protective agent against high blood pressure. Investigating the ACE enzyme
inhibition by kiwifruits generated valuable information for supporting the
general concept that flavonoids rich kiwifruits have health effects.
