Abstract:
In the present paper, the genotoxicity of transgenic Synechocystis sp. PCC 6803 containing flounder (Par alichthys olivaceus) growth hormone gene has been assessed using micronucleus tests in mice and fish. No
micronucleus inductions in bone marrow erythrocyte of mice were observed at three doses of transgenic
Synechocystis (2.0, 5.0, and 10.0 g/kg). The frequencies of micronucleus and other nuclear abnormalities
in turbot (Scophthalmus maximus L.) fed with 0.2%, 0.5% and 1.0% transgenic Synechocystis were also not
significantly different (P > 0.05) from controls. In contrast, cyclophosphamide, used in detecting the sen sitivity of the biological assays, significantly increased the frequencies of micronucleus and other nuclear
abnormalities in mice and turbot. Results indicate that the flounder GH transgenic Synechocystis sp. PCC
6803 seems to have no genotoxic effects on fish