dc.contributor.author |
Hettiarachchi, M. |
|
dc.contributor.author |
Cooke, Rachel |
|
dc.contributor.author |
Norton, Catherine |
|
dc.contributor.author |
Jakeman, Phil |
|
dc.date.accessioned |
2023-07-12T08:35:08Z |
|
dc.date.available |
2023-07-12T08:35:08Z |
|
dc.date.issued |
2019-06-23 |
|
dc.identifier.citation |
Hettiarachchi M, Cooke R, Norton C, Jakeman P. Temporal Change in Biomarkers of Bone Turnover Following Late Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix in Postmenopausal Women with Osteopenia. Nutrients. 2019 Jun 23;11(6):1413. doi: 10.3390/nu11061413. PMID: 31234587; PMCID: PMC6627915. |
en_US |
dc.identifier.uri |
http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/13624 |
|
dc.description.abstract |
The diurnal rhythm of bone remodeling suggests nocturnal dietary intervention to be most effective. This study investigated the effect of bedtime ingestion of a calcium-fortified, milk-derived protein matrix (MBPM) or maltodextrin (CON) on acute (0–4 h) blood and 24-h urinary change in biomarkers of bone remodeling in postmenopausal women with osteopenia. In CON, participants received 804 ± 52 mg calcium, 8.2 ± 3.2 µg vitamin D and 1.3 ± 0.2 g/kg BM protein per day. MBPM increased calcium intake to 1679 ± 196 mg, vitamin D to 9.2 ± 3.1 µg and protein to 1.6 ± 0.2 g/kg BM. Serum C-terminal cross-linked telopeptide of type I collagen (CTX) and procollagen type 1 amino-terminal propeptide (P1NP), and urinary N-telopeptide cross-links of type I collagen (NTX), pyridinoline (PYD) and deoxypyridinoline (DPD) was measured. Analyzed by AUC and compared to CON, a −32% lower CTX (p = 0.011, d = 0.83) and 24% (p = 0.52, d = 0.2) increase in P1NP was observed for MBPM. Mean total 24 h NTX excreted in MBPM was −10% (p = 0.035) lower than CON. Urinary PYD and DPD were unaffected by treatment. This study demonstrates the acute effects of bedtime ingestion of a calcium-fortified, milk-based protein matrix on bone remodeling. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Nutrients |
en_US |
dc.subject |
randomized control trial |
en_US |
dc.subject |
milk protein matrix |
en_US |
dc.subject |
nutrient intervention |
en_US |
dc.subject |
nutrient timing |
en_US |
dc.subject |
bone remodelling |
en_US |
dc.subject |
bone turnover markers |
en_US |
dc.subject |
bone health |
en_US |
dc.subject |
osteopenia |
en_US |
dc.subject |
postmenopausal women |
en_US |
dc.title |
Temporal Change in Biomarkers of Bone Turnover Following Late Evening Ingestion of a Calcium-Fortified, Milk-Based Protein Matrix in Postmenopausal Women with Osteopenia |
en_US |
dc.type |
Article |
en_US |