Membranoproliferative Glomerulonephritis Associated with Hyperthyroid Phase of Autoimmune Thyroiditis

Abstract

Several cases of glomerulonephritis have been associated with autoimmune thyroid diseases. Most frequent renal lesion described was membranous glomerulonephritis presenting with nephrotic syndrome. This is a case history of a 58-year-old male presenting with nephrotic syndrome secondary to membranoproliferative glomerulonephritis and associated autoimmune thyroiditis. Hisserum complement levels were decreased with high titres of circulating antithyroid peroxidase antibodies and thyrotropin receptor antibodies. Renal biopsy showed membranoproliferative glomerulonephritis with the finding of increased tuft cellularity, lobular accentuation,neutrophilinfiltratedglomeruli and thickened basement membrane. Antithyroid drugs along with steroids led to significant reduction in proteinuria and resolution of oedema.