dc.contributor.author |
Karunanayake, A. |
|
dc.contributor.author |
Rajindrajith, S. |
|
dc.contributor.author |
De Silva, H. A. |
|
dc.contributor.author |
Gunawardena, S. |
|
dc.contributor.author |
Devanarayana, N. M. |
|
dc.date.accessioned |
2023-10-23T04:33:44Z |
|
dc.date.available |
2023-10-23T04:33:44Z |
|
dc.date.issued |
2019-01-07 |
|
dc.identifier.citation |
Karunanayake A, Rajindrajith S, de Silva HA, Gunawardena S, Devanarayana NM. Autonomic functions and gastric motility in children with functional abdominal pain disorders. World J Gastroenterol. 2019 Jan 7;25(1):95-106. doi: 10.3748/wjg.v25.i1.95. PMID: 30643361; PMCID: PMC6328964. |
en_US |
dc.identifier.uri |
http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/15221 |
|
dc.description.abstract |
Background: Abdominal pain-predominant functional gastrointestinal disorders (AP-FGIDs) are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly understood.
Aim: To assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of AP-FGIDs.
Methods: One hundred children, fulfilling Rome III criteria for AP-FGIDs, and 50 healthy controls, aged 5 to 12 years, were recruited after obtaining parental consent. All patients were investigated for underlying organic disorders. Gastric motility and cardiovascular autonomic functions were assessed using validated non-invasive techniques.
Results: The main gastric motility parameters assessed (gastric emptying rate [45.7 vs 59.6 in controls], amplitude [48.7 vs 58.2], frequency of antral contractions [8.3 vs 9.4], and antral motility index [4.1 vs 6.4]) were significantly lower in children with AP-FGIDs (P < 0.05). The post-prandial antral dilatation at 1 min after the test meal significantly correlated with the severity of abdominal pain (P < 0.05). Assessment of autonomic functions in AP-FGID patients showed neither a significant difference compared to the control group, nor a correlation with gastric motility abnormalities (P > 0.05). The duration of pain episodes negatively correlated with the parasympathetic tone (maladaptive parasympathetic tone) (P < 0.05).
Conclusion: Children with AP-FGIDs have abnormal gastric motility but normal cardiovascular autonomic functions. There is no relationship between abnormal gastric motility and autonomic functions. The pathogenesis of AP-FGIDs is not related to cardiovascular autonomic dysfunction. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Baishideng Publishing Group Inc. |
en_US |
dc.subject |
Abdominal pain |
en_US |
dc.subject |
Autonomic function |
en_US |
dc.subject |
Functional gastrointestinal disorders |
en_US |
dc.subject |
Gastric motility |
en_US |
dc.title |
Autonomic functions and gastric motility in children with functional abdominal pain disorders |
en_US |
dc.type |
Article |
en_US |