dc.contributor.author |
Cai, J. |
|
dc.contributor.author |
Wang, X. |
|
dc.contributor.author |
Gan, X. |
|
dc.contributor.author |
Zhou, Q. |
|
dc.contributor.author |
Luo, X. |
|
dc.contributor.author |
Yang, B. |
|
dc.contributor.author |
Liu, Y. |
|
dc.contributor.author |
Rathnasekara, Disna |
|
dc.contributor.author |
Zhou, X. |
|
dc.date.accessioned |
2024-03-27T08:45:01Z |
|
dc.date.available |
2024-03-27T08:45:01Z |
|
dc.date.issued |
2022-12-30 |
|
dc.identifier.citation |
Cai, J.; Wang, X.; Gan, X.; Zhou, Q.; Luo, X.; Yang, B.; Liu, Y.; Ratnasekera, D.; Zhou, X. New Chlorinated Metabolites and Antiproliferative Polyketone from the Mangrove Sediments-Derived Fungus Mollisia sp. SCSIO41409. Mar. Drugs 2023, 21, 32. https:// doi.org/10.3390/md21010032 |
en_US |
dc.identifier.issn |
1660-3397 |
|
dc.identifier.uri |
http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/16660 |
|
dc.description.abstract |
Two new chlorinated metabolites, 8-chlorine-5-hydroxy-2,3-dimethyl-7-methoxychromone (1) and 3,4-dichloro-1H-pyrrole-2,5-dione (3), and eight known compounds (2 and 4–9) were isolated from the mangrove sediments-derived fungus Mollisia sp. SCSIO41409. Their structures were elucidated by physicochemical properties and extensive spectroscopic analysis. The absolute configuration of stemphone C (4) was established for the first time by the X-ray crystallographic analysis. Compounds 3 and 4 showed different intensity of antimicrobial activities against several pathogenic fungi and bacteria, and antiproliferative activities against two human prostate cancer cell lines (IC50 values 2.77 to 9.60 µM). Further, stemphone C (4) showed a reducing PC-3 cell colony formation, inducing apoptosis and blocking the cell cycle at S-phase in a dose-dependent manner; thus,it could be considered as a potential antiproliferative agent and a promising anti-prostate cancer lead compound. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Multidisciplinary Digital Publishing Institute (MDPI) |
en_US |
dc.subject |
mangrove sediments-fungus |
en_US |
dc.subject |
Mollisia sp |
en_US |
dc.subject |
chlorinated metabolites |
en_US |
dc.subject |
prostate cancer |
en_US |
dc.subject |
antimicrobial |
en_US |
dc.title |
New Chlorinated Metabolites and Antiproliferative Polyketone from the Mangrove Sediments-Derived Fungus Mollisia sp. SCSIO41409 |
en_US |
dc.type |
Article |
en_US |