Protective Effects of Abelmoschus moschatus Medik. on Adriamycin Induced Oxidative Damage and Inflammation in the Kidney of Wistar Rats

Abstract

Adriamycin is an anthracycline anti-neoplastic drug, in which the use in chemotherapy has been largely limited by its dose related multi-organ toxicities. Oxidative stress and inflammation are the main principles explaining the nephrotoxicity induced by adriamycin. The objective of the study was to investigate the protective effects of selected leaf extracts of Abelmoschus moschatus Medik. (family; Malvaceae, common name: Kapukinissa) on adriamycin induced oxidative damage and inflammation in the kideny of Wistar rats. Soxhlet extraction protocol was followed in the preparation of extracts of A. Moschatus. The experimental rats (n=6/group) induced for nephrotoxicity (adriamycin 5 mg/kg, ip) were administered with hexane, ethyl acetate, butanol, and aqueous extracts of A. Moschatus and the standard drug (fosinopril) orally, at 55, 75, 60, 140 and 0.09 mg/kg doses respectively for 28 consecutive days.