Evaluating the Ability of Sri Lankan FRAX Algorithm to Predict Fracture Risk Without Femoral Neck Bone Mineral Density

Abstract

The application of Fracture Risk Assessment Tool (FRAX) to predict ten-year probability of fragility fractures is restricted in Sri Lanka due to limited availability of Dual Energy X-ray Absorptiometry (DXA) scanners to assess femoral neck bone mineral Density (BMD). The objective of this study is to evaluate the ability of Sri Lankan FRAX algorithm to predict fracture risk of postmenopausal women without using femoral neck BMD data. Postmenopausal women (n=339) were detailed about the research and their written consent was obtained before enrolling into the study. Individual interviews were performed using a content validated datasheet to gather data on clinical risk factors associated with fractures. DXA scans were performed adhering to manufacturer’s protocol. Ten-year risks of major osteoporotic fracture (MOFR) and hip fracture (HFR) were calculated including BMD (FRAX-A) and without including BMD (FRAX-FN0). They were compared to assess the predictability.