Computational study of SARS-CoV-2 Mpro inhibition by  phytochemicals in five traditional medicinal plants

dc.contributor.author	Munasinghe, M.A.I.J.
dc.contributor.author	Ratnaweera, C.N.
dc.date.accessioned	2022-03-14T06:37:07Z
dc.date.available	2022-03-14T06:37:07Z
dc.date.issued	2022-01-19
dc.identifier.issn	1391-8796
dc.identifier.uri	http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/5536
dc.description.abstract	Developing antiviral drugs against the current crisis of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is of high priority among scientific communities. The main viral protease enzyme (Mpro) is a key target of COVID-19 drugs, as the inhibition of which could halt disease progression. In search for potential inhibitors, phytochemicals from Sri Lankan traditional medicinal plants are an invaluable source of drug leads. Therefore, this study utilized molecular docking based virtual screening to evaluate the inhibition of SARS-CoV-2 Mpro by phytochemicals in five medicinal plants that formulate the traditional herbal preparation of ‘paspanguwa’.	en_US
dc.language.iso	en	en_US
dc.publisher	Faculty of Science, University of Ruhuna, Matara, Sri Lanka	en_US
dc.subject	SARS-CoV-2 Mpro,	en_US
dc.subject	COVID-19	en_US
dc.subject	Traditional medicine	en_US
dc.title	Computational study of SARS-CoV-2 Mpro inhibition by phytochemicals in five traditional medicinal plants	en_US
dc.type	Article	en_US