Scholarly Publications: Recent submissions

Now showing items 201-220 of 8285

A Comparative Investigation on Agronomic Traits of Popularly Grown Improved and Traditional Varieties of Rice.

Hafeel, R.F.; Bulugahapitiya, V.P.; Bentota, A.P.; De Zoysa, G.E.D. (Annual sessions of Sri Lanka Association for the Advancement of Science (SLAAS)., 2018)

Rice is the staple food of Sri Lankans and it is available mainly in different categories such as improved and traditional varieties. Presently, most cultivation (99%) are improved rice varieties,while about 1% of ...
10 Quality and Safety of Herbal Medicinal Products

Napagoda, M.; Wijesundara, D.S.A.; Jayasinghe, L. (De Gruyter, 2022)

The World Health Organization defines herbal medicines as plant-derived materials orpreparations intended for human therapeutic use or for other health benefits in hu-mans [1, 2]. Nevertheless, most of the traditional ...
Effect of Alendronate and Vitamin D 3 Treatment on Bone Turnover Markers in Postmenopausal Women with High Fracture Risk: a Double-blind, Randomized Controlled Trial.

Rathnayake, H.; Lekamwasam, S.; Wickramatilake, C.M.; Lenora, J. (80th Annual Academic Sessions of the GMA-(oral), 2021-12)

Background: Bone turnover markers (BTMs) are increased after menopause in women. BTMs are expected to decrease significantly after receiving anti-resorptive treatment in osteoporosis and they can be used to monitor the ...
Association of Bone Turnover Markers with Trabecular Bone Score and Bone Mineral Density among Pre- and Postmenopausal Women: a Study from Sri Lanka

Rathnayake, H.; Lekamwasam, S.; Wickramatilake, C.M.; Lenora, J. (Osteoartheritis and Musculoskeletal Diseases (WCO IOF-ESCEO) (Virtual)-poster, 2021-12)

Objective: Data on the association between bone turnover markers (BTMs) and BMD/trabecular bone score (TBS) are not available for Sri Lankans. This study evaluated the association of serum BTMs with BMD and TBS among pre- ...
Antimicrobial Activity of Leaf Extracts of Litsea iteodaphne (“Kalu Nika”) Against Clinical Isolates of Methicillin Resistant Staphylococcus Aureus

Janesha, U.G.S.; Hasanga, M.R.P.; Hewawasam, R.P.; Wijayaratne, W.M.D.G.B. (2020-11-13)

The use of higher plants to treat infectious diseases is an age-old practice in a large part of the world population, where there is reliance on traditional medicine for a variety of diseases [1]. Interest in plants with ...
In vitro Evaluation of the Antimicrobial Activity of Leaf Extracts of Litsea iteodaphne Against a Selected Group of Bacteria Including Methicillin-Resistant Staphylococcus aureus

Janesha, U.G.S.; Rathnayake, H.; Hewawasam, R.P.; Wijayaratne, W.M.D.G.B. (Wolters Kluwer-Medknow, 2020-05-29)

Background: The quest for scientific endorsement of new drugs from plants continues due to the rising antibiotic resistance against pathogenic bacteria. Litsea iteodaphne is used in Sri Lanka in the treatment of infectious ...
Screeningof the Antibacterial Activities of the Crude Extracts of the Lichen, Parmotrema tinctorum Against Gram Positive and Negative Pathogenic Bacteria

Shiromi, P.S.A.I.; Hasanga, M.R.P.; Hewawasam, R.P.; Wijayaratne, W.M.D.G.B.; Jayalal, R.G.U. (Sabaragamuwa University of Sri Lanka, 2019-11-14)

Among the global health problems in the 21st century, antibiotic resistance is considered as an exigent challenge emerged mainly due to the indiscriminate use of antibiotics during various infectious diseases. Therefore, ...
GSTM2 C Terminus Reduces Calcium Release Through RyR2 in Spontaneously Contracting and Field Stimulated Ventricular Cardiomyocytes

Hewawasam, R.P.; Casarotto, Marco G.; Board, Philip G.; Dulhunty, Angela F. (Elsevier, 2011-02-01)

The ryanodine receptor (RyR) is an ion channel that releases Ca2+ from the sarcoplasmic reticulum and is essential for excitation-contraction coupling and contraction in striated muscle. Previously we reported that the ...
Regulation of the Cardiac Muscle Ryanodine Receptor by Glutathione Transferases

Dulhunty, Angela F.; Hewawasam, R.P.; Dan Liu; Casarotto, Marco G.; Board, Philip G. (Taylor & Francis, 2011-05-01)

Glutathione transferases (GSTs) are generally recognized for their role in phase II detoxification reactions. However, it is becoming increasingly apparent that members of the GST family also have a diverse range of other ...
Screening for Obstructive Sleep Apnoea in Overweight and Obese Children in Southern Sri Lanka

De Silva, M.H.A.D.; Hewawasam, R.P.; Chamika, R.M.A. (Galle Medical Association, 2022-09-27)

Introduction: One of the main risk factors of obstructive sleep apnoea (OSA) is childhood obesity which account for about 60% incidence in obese children. Although polysomnography is the gold standard, it is costly and ...
Aqueous bark Extract of Nauclea Orientalis (Bak mee) Attenuates Doxorubicin Induced Inflammation and Apoptosis in Wistar rats

Sandamali, J.A.N.; Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Faculty of Allied Health Sciences University of Sri Jayewardenepura, 2021)
Electrocardiographic and Biochemical Analysis of Anthracycline Induced Cardiotoxicity in Breast Cancer Patients from Southern Sri Lanka

Sandamali, J.A.N.; Hewawasam, R.P.; Fernando, M.A.C. Sri Sampath; Jayatilaka, K.A.P.W. (BioMed Central, 2023-03-04)

Background: The clinical application of anthracycline chemotherapy is hindered due to the cumulative dose-dependent cardiotoxicity followed by the oxidative stress initiated during the mechanism of action of anthracyclines. ...
The Accuracy of Fatty Liver Index for the Screening of Overweight and Obese Children for Non-alcoholic Fatty Liver Disease in Resource Limited Settings

De Silva, M.H.A.D.; Hewawasam, R.P.; Kulatunge, C.R.; Anjali Chamika, R.M. (BioMed Central, 2022-08-30)

Background: Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease among children with a higher prevalence among obese. Fatty liver index (FLI), an algorithm derived to screen NAFLD using the ...
Cord Leptin, C-Peptide and Insulin Levels in Large for Gestational Age Newborns in Sri Lanka

De Silva, M.H.A.D.; Hewawasam, R.P.; Gayani Iresha, M.A. (Hindawi, 2019-12-16)

Background: Large for gestational age (LGA) infants are more prone to be obese and are at a higher risk of metabolic complications later in life. It is established that Asians have lower skeletal muscle mass and excess ...
Antiurolithiatic Potential of Three Sri Lankan Medicinal Plants by the Inhibition of Nucleation, Growth, and Aggregation of Calcium Oxalate Crystals In Vitro

Hewagama, S.P.; Hewawasam, R.P. (Hindawi, 2022-12-04)

Background: Deposition and formation of stones in any part of the urinary system is called urolithiasis. CaOx is the predominant component of most stones, and the formation of these stones is a multistep process that ...
Antioxidant Effect of Crude Water Extract of Vetiveria Zizanioides (graminae) in mice with Acetaminophen Induced Hepatotoxicity

Hewawasam, R.P.; Jayatilaka, K.A.P.W. (International Journal of Pharmacognosy, 2015-01-01)

Acetaminophen (APAP) is widely used as an analgesic and antipyretic drug. The large dose of APAP results in severe hepatic necrosis due to the oxidative stress. This work evaluates the antioxidant activity of crude water ...
Concordance between Body Composition Indices Measured with Dual-Energy X-Ray Absorptiometry and Bioelectrical Impedance Analysis in Obese Children in Sri Lanka

De Silva, M.H.A.D.; Hewawasam, R.P.; Lekamwasam, S. (Hindawi, 2021-02-13)

Dual-energy X-ray absorptiometry (DXA) is the reference standard in the measurement of body composition indices. But, its utility is limited due to the high cost, expertise required, lack of portability, and restricted ...
Dose Dependent Cardiac Effects of Doxorubicin in Wistar rats: a Biochemical and Histopathological Analysis

Sandamali, J.A.N.; Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Society of Pharmaceutical Sciences and Research, 2019-06-01)

Although doxorubicin is used widely in animal models to induce cardiotoxicity, serial dose-dependent cardiac effects have not been investigated in experimental animal models to date. Therefore, the objective of this study ...
The GSTM2 C-Terminal Domain Depresses Contractility and Ca2+ Transients in Neonatal Rat Ventricular Cardiomyocytes

Hewawasam, R.P.; Dan Liu; Casarotto, Marco G.; Board, Philip G.; Dulhunty, Angela F. (PLOS One, 2016-09-09)

The cardiac ryanodine receptor (RyR2) is an intracellular ion channel that regulates Ca2+ release from the sarcoplasmic reticulum (SR) during excitation-contraction coupling in the heart. The glutathione transferases (GSTs) ...
The Inhibitory Glutathione Transferase M2-2 Binding site is Located in Divergent Region 3 of the Cardiac Ryanodine Receptor

Dan Liu; Hewawasam, R.P.; Karunasekara, Yamuna; Casarotto, Marco G.; Dulhunty, Angela F.; Board, Philip G. (Elsevier, 2012-06-01)

The muscle-specific glutathione transferase GSTM2-2 modulates the activity of ryanodine receptor (RyR) calcium release channels: it inhibits the activity of cardiac RyR (RyR2) channels with high affinity and activates ...

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