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Scholarly Publications: Recent submissions

  • Severe Anaemia and Multiple Ecchymoses in a Postpartum Female Due to Acquired Haemophilia A 
    Palangasinghe, D.R.; Gamage, V.N.U.; Bodinayake, C.K.; Mohotti, M.G.M. (Galle Medical Association, 2017-03-28)
    Acquired haemophilia A (AHA) is a rare acquired bleeding disorder with a worldwide incidence of 2 per million of the population (1). It has a bimodal age distribution including postpartum period and adults over 50 years ...
  • Analysis of Dengue Serotype 4 in Sri Lanka During the 2012–2013 Dengue Epidemic 
    Uehara, Anna; Tissera, H.A.; Bodinayake, C.K.; Amarasinghe, A.; Nagahawatte, A.; Tillekeratne, L.G.; Jie Cui; Reller, Megan E.; Palihawadana, P.; Gunasena, S.; De Silva, A.D.; Wilder-Smith, A.; Gubler, Duane J.; Woods, Christopher W.; Sessions, October M. (The American journal of tropical medicine and hygiene, 2017-07-12)
    The four serotypes of dengue virus (DENV-1, -2, -3, and -4) have had a rapidly expanding geographic range and are now endemic in over 100 tropical and subtropical countries. Sri Lanka has experienced periodic dengue outbreaks ...
  • An Unusual Cause for Periodic Limb Paralysis; Gitelman Syndrome 
    Jayasekara, J.M.S.; Palangasinghe, D.R.; Bodinayake, C.K. (Galle Medical Association, 2018-03-30)
    Gitelman syndrome (GS) is an autosomal recessively inherited salt loosing tubulopathy with a prevalence of 1-10 per 40,000 people (1, 2). The prevalence of GS is higher in Asia than other countries (2). GS is characterized ...
  • Differentiating Scrub Typhus Meningoencephalitis, from Tuberculous Meningitis: Two Case Reports and a Review 
    De Silva, C.M.; Fonseka, C.L.; Nanayakkara, S.D.; Singhapura, S.D.A.L.; Palangasinghe, D.R.; Hewawithana, J.S.; Pathirana, K.D.; Bodinayake, C.K. (Galle Medical Association, 2018-03-01)
    Scrub typhus is a zoonotic disease where currently about one million new cases are identified annually and one billion people may be at risk of this disease (1-3). The infection is acquired through agricultural activities ...
  • Methicillin-resistant Staphylococcus Aureus: Prevalence of and Risk Factors Associated with Colonization of Patients on Admission to the Teaching Hospital, Karapitiya 
    Kurukulasooriya, R.; Tillekeratne, L.G.; Wijayaratne, W.M.D.G.B.; Bodinayake, C.K.; De Silva, A.D.; Nicholson, B.P.; Ostbye, T.; Woods, Christopher W.; Nagahawatte, A. (University of Ruhuna, 2018-12-30)
    Methicillin-resistant Staphylococcus aureus (MRSA) causes a substantial burden of community-acquired and nosocomial infection. Prior colonization with MRSA is a recognized risk factor for MRSA infection. The study aimed ...
  • Evaluation of the WHO 2009 Classification for Diagnosis of Acute Dengue in a Large Cohort of Adults and Children in Sri Lanka During a Dengue-1 Epidemic 
    Bodinayake, C.K.; Tillekeratne, L.G.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Strouse, John J.; Sessions, October M.; Kurukulasooriya, R.; Uehara, Anna; Howe, Shiqin; Xin Mei Ong; Tan, Sharon; Chow, Angelia; Tummalapalli, P.; De Silva, A.D.; Ostbye, T.; Woods, Christopher W.; Gubler, Duane J.; Reller, Megan E. (Public Library of Science (PLOS), 2018-02-09)
    Background Dengue is a leading cause of fever and mimics other acute febrile illnesses (AFI). In 2009, the World Health Organization (WHO) revised criteria for clinical diagnosis of dengue. Methodology/Principal ...
  • Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka 
    Tillekeratne, L.G.; Bodinayake, C.K.; Simmons, R.; Nagahawatte, A.; Devasiri, V.; Arachchi, W.K.; Vanderburg, Sky; Kurukulasooriya, R.; De Silva, A.D.; Ostbye, T.; Reller, Megan E.; Woods, Christopher W. (The American journal of tropical medicine and hygiene, 2018-12-26)
    he contribution of respiratory viruses to acute febrile illness (AFI) burden is poorly characterized. We describe the prevalence, seasonality, and clinical features of respiratory viral infection among AFI admissions in ...
  • Point-prevalence Study of Antimicrobial Use in Public Hospitals in Southern Sri Lanka Identifies Opportunities for Improving Prescribing Practices 
    Tianchen Sheng; Wijayaratne, W.M.D.G.B.; Dabrera, T.M.; Drew, Richard J.; Nagahawatte, A.; Bodinayake, C.K.; Kurukulasooriya, R.; Ostbye, T.; Nagaro, Kristin J.; De Silva, C.; Ranawakaarachchi, H.; Sudarshana, A.T.; Anderson, Deverick J.; Weerasinghe, Christopher W.; Tillekeratne, L.G. (Cambridge University Press, 2019-02-01)
    A point-prevalence study of antimicrobial use among inpatients at 5 public hospitals in Sri Lanka revealed that 54.6% were receiving antimicrobials: 43.1% in medical wards, 68.0% in surgical wards, and 97.6% in intensive ...
  • Extrapulmonary Tuberculosis Presenting as a Dumbbell Tumour of the Chest Wall 
    Kariyawasam, A.G.T.A.; Fonseka, C.L.; Rasnayake, D.; Singhapura, S.D.A.L.; Sanjeewa, A.D.S.; Hewavithana, J.; Masakorala, N.D.; Dahanayake, N.J.; Bodinayake, C.K. (Galle Medical Association, 2019-03-01)
    Tuberculosis gives rise to a significant impact on the healthcare burden in tropical countries where it can present in a variety of ways. The commonest site of tuberculous infection is the lung, while extra-pulmonary ...
  • Use of Clinical Algorithms and Rapid Influenza Testing to Manage Influenza-like Illness: a Cost-effectiveness Analysis in Sri Lanka. 
    Tillekeratne, L.G.; Bodinayake, C.K.; Nagahawatte, A.; Kurukulasooriya, R.; Orlando, Lori A.; Simmons, Ryan A.; Park, Lawrence P.; Woods, Christopher W.; Reed, Shelby D. (BMJ Publishing Group Ltd., 2019-03-30)
    Background Acute respiratory infections are a common reason for antibiotic overuse. We previously showed that providing Sri Lankan clinicians with positive rapid influenza test results was associated with a reduction in ...
  • Geospatial Analysis of Dengue Emergence in Rural Areas in the Southern Province of Sri Lanka 
    Mutucumarana, C.P.; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Kurukulasooriya, R.; Anuradha, T.; De Silva, A.D.; Janko, Mark M.; Ostbye, T.; Gubler, Duane J.; Woods, Christopher W.; Reller, Megan E.; Tillekeratne, L.G.; Lantos, Paul M. (Oxford University Press, 2020-06-01)
    Background: Dengue is a major cause of acute febrile illness in Sri Lanka. Dengue has historically been considered an urban disease. In 2012–2013, we documented that acute dengue was surprisingly associated with self- reported ...
  • Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population 
    Tillekeratne, L.G.; Suchindran, S.; Ko, Emily R.; Petzold, Elizabeth A.; Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Kurukulasooriya, R.; Nicholson, B.P.; McClain, Micah T.; Burke, Thomas W.; Tsalik, Ephraim L.; Henao, Ricardo; Ginsburg, Geoffrey S.; Reller, Megan E.; Woods, Christopher W. (Oxford University Press, 2020-05-26)
    Background. Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately ...
  • Point-prevalence Survey of Outpatient Antibiotic Prescription at a Tertiary Medical Center in Sri Lanka: Opportunities to Improve Prescribing Practices for Respiratory Illnesses 
    Zhang, Helen L.; Bodinayake, C.K.; Wijayaratne, W.M.D.G.B.; Jayatissa, P.; Piyasiri, B.; Kurukulasooriya, R.; Tianchen Sheng; Nagahawatte, A.; Woods, Christopher W.; Tillekeratne, L.G. (BioMed Central (BMC), 2021-01-21)
    Background: Inappropriate antibiotic use is linked to the spread of antimicrobial resistance worldwide, but there are limited systemic data on antibiotic utilization in low- and middle-income countries. The purpose of ...
  • Barriers to Implementing Antimicrobial Stewardship Programs in Three Low- and Middle-income Country Tertiary Care Settings: Findings from a Multi-site Qualitative Study 
    Rolfe Jr, Robert; Kwobah, Charles; Muro, Florida; Ruwanpathirana, A.; Lyamuya, Furaha S.; Bodinayake, C.K.; Nagahawatte, A.; Piyasiri, B.; Tianchen Sheng; Bollinger, J.; Chi Zhang; Truls Ostbye; Ali, Shamim; Drew, R.; Kussin, P.; Anderson, Deverick J.; Woods, Christopher W.; Watt, Melissa H.; Mmbaga, Blandina T.; Tillekeratne, L.G. (Springer Nature, 2021-03-25)
    Background: Antimicrobial resistance has been named as one of the top ten threats to public health in the world. Hospital-based antimicrobial stewardship programs (ASPs) can help reduce antimicrobial resistance. The purpose ...
  • Colonization with Multidrug-resistant Enterobacteriaceae Among Infants: an Observational Study in Southern Sri Lanka 
    Meredith, Hannah R.; Kularathna, S.; Nagaro, Kristin; Nagahawatte, A.; Bodinayake, C.K.; Kurukulasooriya, R.; Wijesingha, N.; Harden, Lyndy B.; Piyasiri, B.; Hammouda, Amr; Wiegmann, Brian M.; Nicholson, B.P.; Joyce, Maria; Woods, Christopher W.; Van Vliet, Arnoud H. M.; Thakur, Siddhartha; Tillekeratne, L.G. (Springer Nature, 2021-04-30)
    Background The timing of and risk factors for intestinal colonization with multidrug-resistant Enterobacteriaceae (MDRE) are still poorly understood in areas with high MDRE carriage. We determined the prevalence, timing, ...
  • The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood 
    Tsalik, Ephraim L.; Fiorino, Cassandra; Aqeel, Ammara; Liu, Yiling; Henao, Ricardo; Ko, Emily R.; Burke, Thomas W.; Reller, Megan E.; Bodinayake, C.K.; Nagahawatte, A.; Arachchi, W.K.; Devasiri, V.; Kurukulasooriya, R.; McClain, Micah T.; Woods, Christopher W.; Ginsburg, G.S.; Tillekeratne, L.G.; Schughart, Klaus (Frontiers Media SA , 2021-10-27)
    Viruses cause a wide spectrum of clinical disease, the majority being acute respiratory infections (ARI). In most cases, ARI symptoms are similar for different viruses although severity can be variable. The objective of ...
  • Knowledge, Perceptions, and Attitudes Regarding Antibiotic Use for Lower Respiratory Tract Infections: Insights from Patients in Sri Lanka. 
    Van Melle, David T.; Asbroek, Guus Ten; Rolfe, R.; Vanderburg, Sky; Abeysinghe, Y. W.; Halloluwa, C.; Zhang, Helen L.; Ostbye, T.; Kurukulasooriya, R.; Tianchen Sheng; Kanchana, S.; Wijayaratne, W.M.D.G.B.; Bodinayake, C.K.; Nagahawatte, A.; Watt, Melissa H.; Woods, Christopher W.; De Silva, P.V.; Tillekeratne, L.G. (American Society of Tropical Medicine and Hygiene, 2021-09-27)
    Antibiotic resistance is an emerging global public health threat. One of the main drivers of this threat is the inappropriate use of antibiotics. In Sri Lanka, antibiotic consumption is increasing, but little is known ...
  • Outcomes Among Children and Adults at Risk of Severe Dengue in Sri Lanka: Opportunity for Outpatient Case Management in Countries with High Disease Burden 
    Bodinayake, C.K.; Nagahawatte, A.; Devasiri, V.; Dahanayake, N.J.; Wijayaratne, W.M.D.G.B.; Weerasinghe, N.P.; Premamali, M.; Tianchen Sheng; Nicholson, B.P.; Ubeysekera, H.A.; Kurukulasooriya, R.; De Silva, A.D.; Ostbye, T.; Woods, Christopher W.; Tillekeratne, L.G. (Public Library of Science (PLOS), 2021-12-28)
    Background Healthcare systems in dengue-endemic countries are often overburdened due to the high number of patients hospitalized according to dengue management guidelines. We systematically evaluated clinical outcomes ...
  • Opportunities for Improving Antimicrobial Stewardship: Findings from a Prospective, Multi-Center Study in Three Low- or Middle-Income Countries 
    Muro, Florida J.; Lyamuya, Furaha S.; Kwobah, C.; Bollinger, J.; Bodinayake, C.K.; Nagahawatte, A.; Piyasiri, B.; Kurukulasooriya, R.; Ali, Shamim; Mallya, R.; Rolfe Jr, R.; Ruwanpathirana, A.; Tianchen Sheng; Østbye, T.; Drew, R.; Kussin, P.; Woods, Christopher W.; Anderson, Deverick J.; Mmbaga, Blandina T.; Tillekeratne, L.G. (Frontiers Media SA, 2022-04-25)
    Background: To develop effective antimicrobial stewardship programs (ASPs) for low- and middle-income countries (LMICs), it is important to identify key targets for improving antimicrobial use. We sought to systematically ...
  • A Practical Approach to Lung Ultrasound Training in Sri Lanka 
    Vanderburg, Sky; Kodikara, I.; Tharakan, Anna; Tianchen Sheng; Gallis, John A.; Sellathurai, M.; Bodinayake, C.K.; Nagahawatte, A.; Wijayaratne, W.M.D.G.B.; Woods, Chris W.; Tillekeratne, L.G.; Riviello, Elisabeth D. (ATS Scholar, 2023-02-28)

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