Abstract:
Study of the spontaneous self-assembly of molecules in
aqueous binary solvent mixture yielding vesicular self-assem blies has been an area of intense research in recent years
because of its tremendous potential application in controlled release drug delivery systems, medical implants, tissue engi neering, etc. Crotocembraneic acid 1, a nano-sized 14-mem bered macrocyclic diterpenic acid, is extractable from the
leaves of Croton oblongifolius Roxb. First self-assembly property
of the nano-sized macrocyclic diterpenoid 1 in aqueous binary
solvent mixtures is reported here. The diterpenoid sponta neously self-assembled in aqueous binary solvent mixtures
yielding vesicles of nano- to micro-meter diameters. The
vesicular self-assemblies were capable of entrapping various
fluorophores including the anticancer drug doxorubicin.
