Abstract:
The study was designed to determine the acute and sub-
chronic toxic effects of aqueous extract of Gmelina arborea (Roxb.) in
healthy male Wistar rats. An aqueous bark extract of G. arborea was
administered at graded doses (0.25-2.00 g/kg) to Wistar rats in the
acute toxicity test. Sub-chronic toxicity was evaluated by daily
administration of the extract at 1.00 g/kg to Wistar rats for 30 days.
All animals were physically active and no death was observed up to
the dose of 2.00 g/kg in the acute toxicity study. The hematological
parameters, serum concentration of liver enzymes and relative organ
weight did not differ significantly in treated rats as compared to
untreated healthy rats (P > 0.05). The histopathological study revealed
no treatment-related gross cellular changes in vital organs in treated
rats. The administration of the bark extract of G. arborea (1.00 g/kg)
was found to be toxicologically safe in Wistar rats.
