Abstract:
Atorvastatin is one of the mostly used statins in treating atherosclerosis. The substandard quality of generic medicines affects their therapeutic efficacy resulting in treatment failure. There are several generics of Atorvastatin available in Sri Lanka. In this study, quality of different brands of Atorvastatin (10 mg tablets) was evaluated using four pharmacopoeial tests such as uniformity of content, friability, weight variation and dissolution test. Uniformity of content of tablets were evaluated by Reversed-phase High- Performance Liquid Chromatography method (RP-HPLC). Other quality tests also were evaluated according to British pharmacopeial specifications.
