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Department of Pharmacology: Recent submissions

Now showing items 1-20 of 33

Vitamin D: Can we use higher doses for wider indications?

Liyanage, P. L. G. C.; Weerarathna, T. P. (Galle Medical Association, 2013-10-01)
Vitamin D and diabetes; a review

Liyanage, P. L. G. C.; Lekamwasam, S.; Weerarathna, T. P.; Minipura, T. (Galle Medical Association, 2016-05-03)
Knowledge, Attitudes, and Practices of Adverse Drug Reaction Reporting Among Healthcare Professionals in Sri Lanka- A Cross Sectional Study

Madhushika, M. T.; Jayasinghe, S. S.; Liyanage, P. L. G. C.; Malinda, W. A. D.; Abeykoon, P. (SAGA Publication, 2023-09-09)

Objectives: The objectives of this study were to describe the knowledge, attitudes and practices of Adverse Drug Reactions (ADR) reporting among healthcare professionals at Teaching Hospital Karapitiya (THK), a tertiary ...
Prevalence of myocardial ischaemia among diabetics determined by validated Sinhala version of the WHO Rose angina questionnaire

Liyanage, P. L. G. C.; Sathananthan, P. P. (Galle Medical Association, 2013-05-08)

Objectives: The aim of this study was to validate the original version of the Rose Angina Questionnaire (RAQ) and apply it to a group of long standing diabetics in a cross-sectional manner to assess it applicability in ...
Comparative Study on Depigmenting Agents in Skin of Color

Liyanage, Achala; Liyanage, P. L. G. C.; Sirimanna, Ganga; Nanna, Schurer (Matrix Medical Communications, 2022-02)

OBJECTIVE: Skin lightening agents are popular in southern Asia, but there is dearth of evidence on their e ectiveness on Fitzpatrick IV/V skin types. This study was designed to assess the depigmenting e cacy of ...
Prevalence and associations of non-alcoholic fatty liver disease (NAFLD) in Sri Lankan patients with type 2 diabetes: A single center study

Herath, H. M. M.; Kodikara, I.; Weerarathna, T. P.; Liyanage, P. L. G. C. (Elsevier, 2019-01-01)

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes for chronic liver disease in Asians. It occurs more commonly in patients with type 2 diabetes mellitus (T2DM). However, data on ...
Hearing impairment in children following bacterial meningitis; assessed with brainstem auditory evoked response (BSAER)

Jayasinghe, S. S.; Pathirana, K. D.; Vimalasena, G. T. H. I. P.; Taranga, D. (Galle Medical Association, 2012-05-29)

Background: Bacterial meningitis is one of the most serious infections occurring in children. Sensorineural hearing loss is the commonest complication of bacterial meningitis. Materials and Methods: We aimed to assess ...
Slow Repetitive Nerve Stimulation in Patients with Acute Organophosphorus Poisoning after Clinical Recovery

Jayasinghe, S. S.; Pathirana, K. D. (Mashhad University of Medical Sciences, 2013-03-01)

Background: Prolonged inhibition of acetylcholine esterase may lead to the intermediate syndrome. Neuromuscular junction (NMJ) dysfunction has been shown with repetitive nerve stimulation (RNS). Subclinical NMJ dysfunction ...
Urinary cystatin C: pediatric reference intervals and comparative assessment as a biomarker of renal injury among children in the regions with high burden of CKDu in Sri Lanka

Sandamini, P. M. M. A.; De Silva, P. Mangala C. S.; Gunasekara, T. D. K. S. C.; Gunarathna, S. D.; Pinipa, R. A. I.; Herath, C.; Jayasinghe, S. S.; Chandana, E. P. S.; Jayasundara, N. (Springer, 2022-02-02)

Background: Cystatin C (Cys-C) is an emerging biomarker of renal diseases and its clinical use, particularly for screening the communities affected by chronic kidney disease of unknown etiology (CKDu), is hindered due to ...
Arsenic and human health effects: A review

Chandana, E.P.S.; Jayasumana, C.; De Silva, P.M.C.S.; Abdul, K.S.M.; (Elsevier, 2015-11-01)

Arsenic (As) is ubiquitous in nature and humans being exposed to arsenic via atmospheric air, ground water and food sources are certain. Major sources of arsenic contamination could be either through geological or via ...
Lipid abnormalities in type 2 diabetes mellitus patients in Sri Lanka

Hettihewa, L. M.; Gunasekera, S. W.; Jayasinghe, S. S.; Palangasinghe, S.; Weerarathna, T. P.; Kotapola, I. (Galle Medical Association, 2009-09-25)

Background & Objective: Previous studies suggest that the prevalence of dyslipidaemia in type 2 diabetes is high with respect to the general population. But data related to the prevalence of dyslipidaemia in ...
Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation

Hettihewa, L. M.; Jayasinghe, S. S.; Weerarathna, T. P.; Gunasekara, S. W.; Palangasinghe, S.; Kotapola, I. (OJHAS, 2005-05-10)

We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients. IR was assessed by fasting insulin test ...
Correlation between changes of blood pressure with insulin resistance in type 2 diabetes mellitus with 4 weeks of pioglitazone therapy

Hettihewa, L. M.; Jayasinghe, S. S.; Imendra, K. G.; Weerarathna, T. P. (Springer, 2008-01)

Objective: To examine effects of pioglitazone (PIO) on systolic, diastolic, pulse and mean blood pressures (SBP, DBP, PP and MP, respectively) in type 2 diabetes mellitus (T2DM). Materials and methods: One hundred and ...
Correlation between BMI and insulin resistance in type 2 diabetes mellitus patients on pioglitazone treatment

Hettihewa, L. M.; Dharmasira, L. P.; Ariyaratne, C. D.; Jayasinghe, S. S.; Weerarathna, T. P.; Kotapola, I. G. (Galle Medical Association, 2009-09-25)

doi: 10.4038/gmj.v12i1.1080 Galle Medical Journal Vol.12(1) 2007 18-24
Simple and sensitive liquid chromatography–tandem mass spectrometry methods for quantification of paraquat in plasma and urine: Application to experimental and clinical toxicological studies

Wunnapuk, Klintean; Medley, Gregory A.; Liu, Xin; Grice, Jeffrey E.; Jayasinghe, S. S.; Gawarammana, I.; Buckley, Nicholas A.; Roberts, Michael S. (Elsevier, 2011-10-15)

Simple, sensitive and specific liquid chromatography–tandem mass spectrometry (LC–MS/MS) methods have been developed and validated for quantification of paraquat (PQ) in plasma and urine. Plasma and urine sample preparation ...
Correlation between BMI and insulin resistance in type 2 diabetes mellitus patients on pioglitazone treatment

Hettihewa, L. M.; Dharmasira, L. P.; Ariyaratne, C. D.; Jayasinghe, S. S.; Weerarathna, T. P.; Kotapola, I. G. (Galle Medical Association, 2009-09-25)

doi: 10.4038/gmj.v12i1.1080 Galle Medical Journal Vol.12(1) 2007 18-24
Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka

De Silva, P. M. C. S.; Abdul, K.S.M.; Ekanayake, E. M. D. V.; Jayasumana, C.; Jayasinghe, S. S.; Asanthi, H. B.; Perera, H. S. D.; Chaminda, G. G. T.; Chandana, E. P. S.; Siribaddana, S. H. (PLOS, 2019-09-19)

Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that ...
Administration of paracetamol to children; do parents adhere to recommendations?

Wanni Arachchi, T. I.; Gamage, M. W. K.; Jayasinghe, S. S. (Galle Medical Association, 2018-12-31)

Introduction: Fever is a common health problem in childhood. Parents often administer paracetamol to children without consulting a doctor since it is a widely available over the counter drug. The aim of this study was to ...
The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review

Gunasekara, T. D. K. S. C.; De Silva, P. Mangala C. S.; Herath, C.; Siribaddana, S.; Siribaddana, N.; Jayasumana, C.; Jayasinghe, S. S.; Cardenas-Gonzalez, Maria; Jayasundara, Nishad (MDPI, 2020-12-18)

Chronic Kidney Disease (CKD) is a globally prevalent non-communicable disease with significant mortality and morbidity. It is typically associated with diabetes and hypertension; however, over the last two decades, an ...
Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka

Abdul, K.S.M.; De Silva, P.M.C.S.; Ekanayake, E.M.D.V.; Thakshila, W.A.K.G.; Gunarathna, S.D.; Gunasekara, T.D.K.S.C.; Jayasinghe, S.S.; Asanthi, H.B.; Chandana, E.P.S.; Chaminda, G.G.T.; Siribaddana, S.H.; Jayasundara, N. (MDPI, 2021-03-22)

Extensive use of herbicides is common among rural agricultural workers in Sri Lanka. Recent studies have postulated their role in the development of chronic kidney disease of unknown etiology (CKDu). Paraquat and glyphosate ...

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