Abstract:
Type 2 diabetes is a complex disease that involves
insulin secretion abnormalities and defects in the
action of insulin on its target tissues. This chronic
metabolic disorder is associated with high
mortality and morbidity from long-term
microvascular and macrovascular complications
[1]. Thiazolidinediones (pioglitazone, rosiglitazone,
and troglitazone) are synthetic peroxisomes
proliferated receptor-ã agonists that decrease
insulin resistance, may also have direct beneficial
effects on pancreatic â cells [2].
Previous reports shows that decrease in fasting
plasma insulin with pioglitazone associated with
the improvement of insulin sensitivity [2].
Treatment with pioglitazone was associated with
beneficial effects on blood lipid levels as well. Here
we present a patient who got a remission of type
2 diabetes mellitus after 2 months of pioglitazone therapy (15 mg)