dc.contributor.author |
Sandamali, J.A.N. |
|
dc.contributor.author |
Hewawasam, R.P. |
|
dc.contributor.author |
Jayatilaka, K.A.P.W. |
|
dc.contributor.author |
Mudduwa, L.K.B. |
|
dc.date.accessioned |
2023-01-11T09:17:18Z |
|
dc.date.available |
2023-01-11T09:17:18Z |
|
dc.date.issued |
2020-03-16 |
|
dc.identifier.citation |
Sandamali, J.A.N., Hewawasam, R.P., Jayatilaka, K.A.P.W., Mudduwa, L.K.B., 2020. Cardioprotective potential of Murraya koenigii (L.) Spreng. leaf extract against doxorubicin-induced cardiotoxicity in rats. Evidence-Based Complementary and Alternative Medicine. doi: 10.1155/2020/6023737. |
en_US |
dc.identifier.issn |
1741-427X |
|
dc.identifier.issn |
1741-4288 |
|
dc.identifier.uri |
http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/10150 |
|
dc.description.abstract |
Dose-dependent cardiotoxicity of doxorubicin may lead to irreversible congestive heart failure. Although multiple mechanisms
are involved, generation of free radicals is the most commonly postulated mechanism. +erefore, free radical scavengers are
considered as potential therapeutic agents. As Murraya koenigii leaves are a rich source of flavonoids and phenols, they have the
ability to scavenge free radicals effectively. +erefore, the objective of this study was to investigate the cardioprotective potential of
Murraya leaf extract against doxorubicin-induced cardiotoxicity in rats. Rats were randomly divided into five groups with 10
animals in each group. Doxorubicin was administered intraperitonially at 18 mg/kg while lyophilized plant extract was ad ministered orally at 2 g/kg. Dexrazoxane, at 180 mg/kg, was used as the positive control. Cardiac damage of doxorubicin control
was evident with a significant increase (p < 0.05) in cardiac troponin I, NT-pro BNP, AST, and LDH compared to the normal
control. Plant-treated group showed cardioprotective effect by significantly reducing (p < 0.05) all of the above parameters
compared to doxorubicin control (p < 0.05). Increased oxidative stress in doxorubicin control was evident with a significant
reduction in reduced glutathione, glutathione reductase, glutathione peroxidase, total antioxidant capacity, superoxide dismutase,
and catalase activity and a significant increase in lipid peroxidation compared to the control. Interestingly, treatment with
Murraya leaf extract showed a significant increase in all of the above antioxidant parameters and a significant reduction in lipid
peroxidation by showing an antioxidant effect. A significant increase in myeloperoxidase activity confirmed the increased in flammatory activity in doxorubicin control group whereas plant-treated group showed a significant reduction (p < 0.05) which
expressed the anti-inflammatory effect of Murraya leaf extract. Doxorubicin-treated group showed histological evidence of
extensive damage to the myocardium while plant-treated group showed a preserved myocardium with lesser degree of damage.
Pretreatment with Murraya leaf extract may replenish cardiomyocytes with antioxidants and promote the defense against
doxorubicin-induced cardiotoxicity. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Hindawi |
en_US |
dc.subject |
Doxorubicin |
en_US |
dc.subject |
cardiotoxicity |
en_US |
dc.subject |
Murraya koenigii leaf extract |
en_US |
dc.subject |
cardioprotectivity |
en_US |
dc.subject |
antioxidant effect |
en_US |
dc.title |
Cardioprotective potential of Murraya koenigii (L.) Spreng. leaf extract against doxorubicin-induced cardiotoxicity in rats |
en_US |
dc.type |
Article |
en_US |