Abstract:
Hypothyroidism is a relatively common chronic disease affecting 2-3% of general population worldwide.
Treatment is life-long levothyroxine. The main problem with treatment for any chronic disease is poor drug
compliance. Major influence for drug compliance is caused by patient related factors. This study aims to
investigate how patient related factors affect the compliance for levothyroxine therapy. To find out Association of Patient Related Factors on Drug Compliance for levothyroxine therapy. This was a questionnaire based cross sectional study which was conducted in Diabetes and Endocrine Unit,
Teaching Hospital, Karapitiya. First 100 individuals attending the endocrinology clinic with the diagnosis of
hypothyroidism on replacement levothyroxine therapy were selected by convenience sampling. Compliance
was measured using a modified version of a study instrument which was used on patients with hypertension,
another non-communicable disease. Total composite score of this instrument was 13 and an arbitrary value 10
was selected as the cut-off for non-compliance. A score of above 10 indicated high compliance. Chi-square test
was applied to compare the compliance status with patient related factors. Hypothyroidism was most common in the age category of 45-54yrs. Among participants, 87% were females.
The total compliance rate for levothyroxine therapy in this study was 65%. There was no significant difference in
compliance with different socio-demographic groups (i.e. age, gender, ethnicity, marital status, occupational
status, monthly income, and educational level), duration of the illness, number of co-morbidities, knowledge
about hypothyroidism or status of physical impairment. There was a significantly higher compliance in the group
in which the “doctor strongly emphasized the importance of taking medication regularly”, studied under the
patient prescriber relationship (chi-square value 4.071, table value at 5% 3.841). Other behaviors of prescriber
which were under the patient prescriber relationship did not show any significant influence on compliance. The
distance to the clinic also had a significant influence on compliance (chi-square value 7.091, table value at 5%
5.991).