Citation:da Silva, G. S., Shang, Z., Kalansuriya, P., Capon, R. J., & Espósito, B. P. (2019). Antioxidant activity and cellular uptake of the hydroxamate-based fungal iron chelators pyridoxatin, desferriastechrome and desferricoprogen. Biometals, 32, 707-715.
Date:2019-06-01
Abstract:
The hydroxamate class of compounds is
well known for its pharmacological applications,
especially in the context of chelation therapy. In this
work we investigate the performance of the fungal
hydroxamates pyridoxatin (PYR), desferriastechrome
(DAC) and desferricoprogen (DCO) as mitigators of
stress caused by iron overload (IO) both in buffered
medium and in cells. Desferrioxamine (DFO), the gold
standard for IO treatment, was used as comparison. It
was observed that all the fungal chelators (in aqueous
medium) or PYR and DAC (in cells) are powerful iron
scavengers. However only PYR and DCO (in aqueous
medium) or PYR (in cells) were also antioxidant
against two forms of iron-dependent oxidative stress
(ascorbate or peroxide oxidation). These findings
reveal that PYR is an interesting alternative to DFO
for iron chelation therapy, since it has the advantage of
being cell permeable and thus potentially orally active.