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Browsing Department of Biochemistry by Issue Date

Browsing Department of Biochemistry by Issue Date

Now showing items 1-20 of 153

Evaluation of the efficacy of Melothria maderaspatana in the alleviation of carbon tetrachloride-induced liver dysfunction

Thabrew, M. I.; Jayatilaka, K. A.; Perera, D. J. (Elsevier, 1988-07-01)

An investigation was carried out to evaluate the ability of Melothria maderaspatana to protect the livers of albino rats from carbon tetrachloride-mediated alterations in liver histopathology and serum levels of alanine ...
An evaluation of the potency of Osbeckia octandra and Melothria maderaspantana as antihepatotoxic agents

Jayatilaka, K. A.; Thabrew, M. I.; Pathirana, C.; De Silva, D. G.; Perera, D. J. (Planta Med, 1989-04)

Aqueous extracts of the aerial parts of Melothria maderasptana and the leaves of Osbeckia octandra have been compared with (+)-3-cyanidanol with regard to their abilities to alleviate carbon tetrachloride (CCl4)-induced ...
Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity

Jayatilaka, K. A.; Thabrew, M. I.; Perera, D. J. (Elsevier, 1990-08-01)

Treatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or after CCl4 administration in rats markedly decreased CCl4-mediated reductions in aniline hydroxylase and p-aminopyrine ...
A comparative study of the beneficial effects of Osbeckia octandra and Osbeckia aspera in liver dysfunction in rats

Thabrew, M. I.; Jayatilaka, K. A. P. W. (Ceylon Journal of Medical Science, 1999-06-29)
Protection by Osbeckia aspera against carbon tetrachloride-mediated alterations in microsomal drug metabolizing enzyme activity

Jayatilaka, K. A.; Thabrew, M. I. (J Pharm Pharmacol ., 2000-04)

Previous investigations have con®rmed the protective effect of Osbeckia aspera leaf extract on carbon tetrachloride-mediated liver injury in rat models. It is well known that the earliest alterations in liver cell structure ...
BIOACTIVITY STUDIES OF SOME SRI LANKAN FLORA AND BIOACTIVE XANTHONES FROM CALOPHYLLUM THWAITESII

Napagoda, M. (UNIVERSITY OF PERADENTYA, 2005)
Elimination of Iodine Deficiency Disorders (IDD) in Lanka: Does our salt industry comply with SLS guidelines for salt iodization?

De Zoysa, G. E. D.; Hettiarachchi, M.; Jayatilaka, K. A. P. W.; Liyanage, C. (125th Anniversary International Medical Congress of the Sri Lanka Medical Association., 2012)
Iodine content of commercially available salt products in Bope – Poddala Health Division in Galle: Need of urgent intervention for a proper programme monitoring

De Zoysa, G. E. D; Hettiarachchi, M.; Jayatilaka, K. A. P. W.; Liyanage, C. (9th Academic Sessions, University of Ruhuna., 2012-02-22)
Testosterone: a promising adjuvant for a failing heart?

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Journal of the Ceylon College of Physicians, 2012-08-08)

Among the chronic diseases which occur with advancing age, chronic heart failure (CHF) remains one of the leading causes of morbidity and mortality worldwide. In patients with nonedematous cachetic heart failure, the ...
Study of antihyperglycaemic activity of medicinal plant extracts in alloxan induced diabetic rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (ResearchGate, 2013-04)

Background: Diabetes mellitus, for a long time, has been treated with plant derived medicines in Sri Lanka. Aim: The aim of this study is to determine the efficacy and dose response of oral antihyperglycaemic activity ...
Fluctuations of testosterone in acute coronary syndrome

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2013-05-07)

Objective: Fluctuations of serum testosterone after acute coronary syndrome (ACS) are infrequently reported. This study was done to determine the optimal time point for blood sampling for testosterone levels after ACS and ...
Isolation and Identification of Lipase Producing Fungi and Partial Characterization of Their Lipase

Rathnayake, H.; Samaraweera, P. (The University of Peradeniya, 2013-07-04)

Lipases catalyze the hydrolysis of ester bonds in triacylglycerols resulting fatty acids and glycerol. Lipase is a major commercial enzyme which has a wide range of industrial and biotechnological applications. Lipases are ...
Azahelicene Superbases as MAILD Matrices for Acidic Analytes

Napagoda, M.; Rulíšek, Lubomír; Jančařík, Andrej; Klívar, Jiří; Šámal, Michal; Stará, Irena G.; Starý, Ivo; Šolínová, Veronika; Kašička, Václav; Svatos, Ales (Wiley-VCH Verlag GmbH&Co., 2013-08-19)

Fitting the profile: A superbasic 1,14-diaza[5]helicene can serve as an efficient, ionless matrix for matrix-assisted ionization/laser desorption (MAILD) spectrometry. The matrix outperforms other bases by acting as a ...
Azahelicene Superbases as MAILD Matrices for Acidic Analytes

Napagoda, M.; Rulíšek, Lubomír; Jančařík, Andrej; Klívar, Jiří; Šámal, Michal; Stará, Irena G.; Starý, Ivo; Šolínová, Veronika; Kašička, Václav; Svatoš, Aleš (WILEY‐VCH Verlag, 2013-09)

Fitting the profile: A superbasic 1,14-diaza[5]helicene can serve as an efficient, ionless matrix for matrix-assisted ionization/laser desorption (MAILD) spectrometry. The matrix outperforms other bases by acting as a ...
Association of serum testosterone with lipid abnormalities in patients with angiographically proven coronary artery disease

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Indian J Endocrinol Metab, 2013-11-01)

Context: Low testosterone levels are associated with an atherogenic lipid proﬁ le and may contribute to the pathogenesis of atherosclerosis. Aims: Our study aimed to investigate the relationship between serum total ...
Efficacy and toxicological evaluation of Coccinia grandis (Cucurbitaceae) extract in male Wistar rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (Elsevier, 2013-12)

Objective To investigate the oral antihyperglycemic effect of aqueous leaf extract of Coccinia grandis (L.) (Cucurbitaceae) along with toxicological effects in alloxan induced diabetic and healthy Wistar rats. Methods A ...
Is the Universal Salt Iodization programme implemented in Sri Lanka effective in maintaining iodine nutrition throughout the pregnancy?

De Zoysa, G. E. D; Hettiarachchi, M.; Jayatilaka, K. A. P. W.; Liyanage, K. D. C. E. (127th Anniversary International Medical Congress of the Sri Lanka Medical Association., 2014)
Antihyperglycaemic,antihyperlipidaemic and cell regenerative effects of Spondias pinnata (Linn. f.)Kurz.bark extract on streptozotocin induced diabetic rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (Elsevier, 2014)
Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach

Napagoda, M.; Gerstmeier, J.; Wesely, Sandra; Popella, Sven; Lorenz, Sybille; Scheubert, Kerstin; Svatoš, Aleš; Werz, Oliver (Elsevier, 2014-02-03)

Ethnopharmacological relevance: The perennial herb Plectranthus zeylanicus Benth is extensively used in traditional medicine in Sri Lanka and South India for treating inflammatory conditions, but pharmacological features ...
Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1

Napagoda, M.; Gerstmeier, J.; Koeberle, A.; Wesely, Sandra; Popella, Sven; Lorenz, Sybille; Scheubert, Kerstin; Böcker, Sebastian; Svatoš, Aleš; Werz, Oliver (Elsevier, 2014-02-03)

Ethnopharmacological relevance: Preparations from Munronia pinnata (Wall.) Theob. are extensively used in traditional medicine in Sri Lanka for the treatment of inflammatory conditions. However, neither the pharmacological ...

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