Abstract:
Treatment with an aqueous extract of the aerial parts of Melothria maderaspatana, before or
after CCl4 administration in rats markedly decreased CCl4-mediated reductions in aniline
hydroxylase and p-aminopyrine N-demethylase activities. Phenobarbital-induced sleeping time
in rats and kinetic enzyme studies showed that the effect of the plant was neither due to an
induction of the drug metabolizing enzymes nor due to an alteration in the Km values of the
enzymes.
