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Browsing Department of Biochemistry by Author

Browsing Department of Biochemistry by Author "Pathirana, C."

Now showing items 1-20 of 23

Acute hypoglycemic and antihyperglycemic effects of ten Sri Lankan medicinal plant extracts in healthy and streptozotocin induced diabetic rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (Springer Link, 2014-07-25)

The efficacy and dose response of oral hypoglycemic and antihyperglycemic effects of ten Sri Lankan plant extracts on glucose tolerance were evaluated in healthy and streptozotocin induced diabetic rats. A single dose of ...
Antihyperglycaemic,antihyperlipidaemic and cell regenerative effects of Spondias pinnata (Linn. f.)Kurz.bark extract on streptozotocin induced diabetic rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (Elsevier, 2014)
Antihyperglycemic activity of Coccinia grandis (L.) Voigt in streptozotocin induced diabetic rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (NISCAIR-CSIR, India, 2015-07-01)

Coccinia grandis (L.) Voigt (Cucurbitaceae) has been popularly used in traditional Ayurvedic medicine for the treatment of diabetes mellitus in Sri Lanka. The present study was to investigate the long term effect of aqueous ...
Antioxidant activity of Gmelina arborea Roxb. (Verbenaceae) bark extract: In vivo and in vitro study

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (Medknow, 2014-12-05)

Context: Gmelina arborea Roxb (Family: Verbenaceae) is widely used in Sri Lankan traditional Ayurvedic medicine for long -term treatment of diabetes mellitus. Aims: To investigate the in vitro and in vivo antioxidant ...
Association between anthropometric parameters and testosterone deficiency in men

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Sri Lanka Journal of Diabetes, 2014-08)

Objectives: Obesity and anthropometric measures are related to the testosterone concentration in men, although debate remains as to which anthropometric parameters are most important. Fat mass or adiposity is an important ...
Association of metabolic syndrome with testosterone and inflammation in men

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Elsevier, 2015-07)

Objective: There is limited data on the assessment of relationship between sex hormones, metabolic syndrome (MS) and inflammation. Therefore, our objective was to examine the relationship between metabolic syndrome, ...
Association of serum testosterone with lipid abnormalities in patients with angiographically proven coronary artery disease

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Indian J Endocrinol Metab, 2013-11-01)

Context: Low testosterone levels are associated with an atherogenic lipid proﬁ le and may contribute to the pathogenesis of atherosclerosis. Aims: Our study aimed to investigate the relationship between serum total ...
ASSOCIATION OF SERUM TESTOSTERONE WITH THE COMPLICATIONS OF ACUTE MYOCARDIAL INFARCTION

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Pakistan Cardiac Society , 2014-12-20)

Objective: The objectives of the study were to assess (1) if serum levels of testosterone differ between men with and those without ST-elevation myocardial infarction, and (2) to determine the association of testosterone ...
Association of testosterone, inflammation with the severity of first acute ST-elevation myocardial infarction

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Elsevier, 2017-03)

Men with ischemic heart disease (IHD) are found to have low serum testosterone concentration and it is associated with chronic vascular and systemic inflammation. However, the findings are conflicting and warrant further ...
Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Mudduwa, L. K. B.; Pathirana, C. (Hindawi, 2018-06-12)

The objective of the present study was to investigate the effect of refluxed aqueous extracts of Gmelina arborea, Spondias pinnata, and Coccinia grandis on atherogenicity and oxidative stress in rats with chemically induced ...
Efficacy and toxicological evaluation of Coccinia grandis (Cucurbitaceae) extract in male Wistar rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (Elsevier, 2013-12)

Objective To investigate the oral antihyperglycemic effect of aqueous leaf extract of Coccinia grandis (L.) (Cucurbitaceae) along with toxicological effects in alloxan induced diabetic and healthy Wistar rats. Methods A ...
An evaluation of the potency of Osbeckia octandra and Melothria maderaspantana as antihepatotoxic agents

Jayatilaka, K. A.; Thabrew, M. I.; Pathirana, C.; De Silva, D. G.; Perera, D. J. (Planta Med, 1989-04)

Aqueous extracts of the aerial parts of Melothria maderasptana and the leaves of Osbeckia octandra have been compared with (+)-3-cyanidanol with regard to their abilities to alleviate carbon tetrachloride (CCl4)-induced ...
Fluctuations of high-sensitivity C-reactive protein in acute coronary syndrome

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Galle Medical Journal, 2014-06-02)

Background: Atherosclerosis is associated with low-grade vascular inflammation that can be measured with high sensitivity-C reactive protein (hs-CRP). Acute coronary syndrome (ACS) events are thought to occur due to plaque ...
Fluctuations of testosterone in acute coronary syndrome

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2013-05-07)

Objective: Fluctuations of serum testosterone after acute coronary syndrome (ACS) are infrequently reported. This study was done to determine the optimal time point for blood sampling for testosterone levels after ACS and ...
Gmelina arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (PubMed Central, 2016-01-06)

Gmelina arborea Roxb. (common name: Et-demata, Family: Verbenaceae) has been used traditionally in Sri Lanka as a remedy against diabetes mellitus. The objective of the present study was to evaluate antidiabetic mechanisms ...
High-sensitivity C-reactive protein in Sri Lankan males with coronary artery disease

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Ibn Sina Trust, 2016-04-11)

Objectives: Evidence suggests that inflammation and dyslipideamia play a key role in the pathogenesis of coronary artery disease (CAD). High sensitivity C-reactive protein (hsCRP) is a sensitive marker of inflammation. We ...
Metabolic profile, obesity and overweight among Sri Lankan males with ischaemic heart disease: A single centre experience

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Galle Medical Association, 2019-03-30)

Introduction: Obesity is a significant risk factor for ischaemic heart disease (IHD). Asians who are not overweight or obese tend to have IHD and develop metabolic derangements in their early life. We investigated the ...
Phytochemical screening and in vitro antioxidative potential of ten medicinal plant extracts used traditionally for the treatment of diabetes mellitus in Sri Lanka

Attanayake, A. P.; Jayatilaka, K. A. P. W.; Pathirana, C.; Mudduwa, L. K. B. (African Journal of Traditional, 2015-07)

Background: Over the last decade, extensive research work has focused on the potential health benefits of antioxidants while many medicinal plantextracts have been evaluated for their antioxidant profile. Medicinal plants ...
Predictability of adverse clinical events following ST-elevation myocardial infarction by risk assessment tools

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Galle Medical Association, 2016-05-03)

Background: Killip classes, TIMI and GRACE scores are simple validated clinical risk scores used in risk stratification in acute coronary syndrome including ST-elevation myocardial infarction (STEMI). Objectives: Our ...
Premature coronary artery disease and testosterone in Sri Lankan men

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2014-08-01)

Objective: Recent studies have shown that low endogenous testosterone in men is associated with coronary artery disease (CAD) and its risk factors such as obesity, hypertension, dyslipidaemia, and diabetes mellitus. This ...

Browsing Department of Biochemistry by Author "Pathirana, C."

Browsing Department of Biochemistry by Author "Pathirana, C."

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