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Department of Biochemistry: Recent submissions

Now showing items 1-20 of 153

Identification of plant based anti-diabetic drug leads: A computer-based drug discovery approach

Katipearachchi, S. H.; Faizan, M.; Kalansuriya, P.; Attanayake, A. P. (Faculty of Science, University of Kelaniya, Sri Lanka, 2023-10-13)

Diabetes mellitus is known to be one of the fastest-rising chronic metabolic diseases with multiple etiologies. The disease is characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin ...
Antimicrobial and Antifungal Activities of Silver Nanoparticles Biosynthesized by Pothos scandens and Kaempferia galanga Aqueous Extracts

Samadhi, K. G. A.; Kalansuriya, P.; Wijeratne, W. M. D. G. B.; Wasana, K. G. P. (Faculty of Science, University of Kelaniya, Sri Lanka, 2023-10-13)

In order to alleviate the clinical challenges associated with antibiotic use, there is an immediate need for innovative solutions. Utilizing nanotechnology-based antimicrobials represents a promising approach to enhance ...
Isolation and Identification of Lipase Producing Fungi and Partial Characterization of Their Lipase

Rathnayake, H.; Samaraweera, P. (The University of Peradeniya, 2013-07-04)

Lipases catalyze the hydrolysis of ester bonds in triacylglycerols resulting fatty acids and glycerol. Lipase is a major commercial enzyme which has a wide range of industrial and biotechnological applications. Lipases are ...
Prediction of appendicular skeletal muscle mass of older women using anthropometry-based equations

Rathnayake, N.; Lekamwasam, S.; Rathnayake, H. (Ceylon Medical Journal, 2021-07-30)

We evaluated the accuracy of two anthropometry-based equations, initially developed for middle-aged women for estimating appendicular skeletal muscle mass (ASMM), when applied to a group of older women. Weight (kg), height ...
Comparison of In Vitro Antibacterial Activity of Epaltes divaricata and Vetiveria zizanioides against Methicillin-Resistant Staphylococcus aureus

Rathnayake, H.; De Zoysa, M. H. N.; Hewawasam, R. P.; Wijayaratne, W. M. D. G. B. (Hindawi, 2020-07-14)

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital- and community-acquired infections worldwide. Therefore, this study was conducted to explore the antibacterial activity of the two medicinal ...
Chemical Composition and Antimicrobial Activity of Two Sri Lankan Lichens, Parmotrema rampoddense, and Parmotrema tinctorum against Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus

Shiromi, P. S. A. I.; Hewawasam, R. P.; Jayalal, R. G. U.; Rathnayake, H.; Wijayaratne, W. M. D. G. B.; Wanniarachchi, D. (Hindawi, 2021-06-02)

Introduction. Medicinal utility of lichens is ascribed to the presence of various secondary metabolites of low molecular weight and they have been used in traditional medicine including Ayurveda in the treatment of wounds ...
Determination of In Vitro Antimicrobial Activity of Five Sri Lankan Medicinal Plants against Selected Human Pathogenic Bacteria

De Zoysa, M. H. N.; Rathnayake, H.; Hewawasam, R. P.; Wijayaratne, W. M. D. G. B. (Hindawi, 2019-05-06)

Introduction. Antibiotic resistance is one of the greatest threats of the 21st century. Scientists search for potential antimicrobial sources that can cope with antibiotic resistance. Plants used in traditional medicine ...
Microwave assisted accelerated fluoride adsorption by porous nanohydroxyapatite

Wimalasiri, A. K. D. V. K.; Fernando, M. Shanika; Williams, Gareth R.; Dissanayake, D. P.; De Silva, K. M. N.; De Silva, R. M. (Elsevier, 2021-01-01)

Fluoride pollution of water is a matter of concern in many countries due to its association with chronic kidney failure. Therefore, it is important to develop fast and efficient methods for fluoride removal from drinking ...
Biopolymer-Based Nanohydroxyapatite Composites for the Removal of Fluoride, Lead, Cadmium, and Arsenic from Water

Fernando, M. Shanika; Wimalasiri, A. K. D. V. K.; Dziemidowicz, Karolina; Williams, Gareth R.; Koswattage, K. R.; Dissanayake, D. P.; De Silva, K. M. N.; De Silva, R. M. (American Chemical Society, 2021-03-18)

In this study, hydroxyapatite (HAP) nanocomposites were prepared with chitosan (HAP-CTS), carboxymethyl cellulose (HAP-CMC), alginate (HAP-ALG), and gelatin (HAP-GEL) using a simple wet chemical in situ precipitation method. ...
Improved nanocomposite of montmorillonite and hydroxyapatite for defluoridation of water

Fernando, M. Shanika; Wimalasiri, A. K. D. V. K.; Rathnayake, S. P.; Jayasinghe, J. M. A. R. B.; William, Gareth R.; Dissanayake, D. P.; De Silva, K. M. N.; De Silva, R. M. (Royal society of chemistry, 2019-11-01)

A novel hydroxyapatite montmorillonite (HAP-MMT) nanocomposite system was synthesized using a simple wet chemical in situ precipitation method. Neat nano hydroxyapatite (HAP) was also synthesized for comparison. The ...
Structure–Activity Relationship of Lanthanide-Incorporated Nano-Hydroxyapatite for the Adsorption of Fluoride and Lead

Wimalasiri, A. K. D. V. K.; Fernando, M. Shanika; Dziemidowicz, Karolina; Williams, Gareth R.; Koswattage, K. R.; Dissanayake, D. P.; De Silva, K. M. N.; De Silva, R. M. (American Chemical Society, 2021-05-17)

The growing demand for water purification provided the initial momentum to produce lanthanide-incorporated nano-hydroxyapatite (HAP) such as HAP·CeO2, HAP·CeO2·La(OH)3 (2:1), and HAP·CeO2·La(OH)3 (3:2). These materials ...
Controlled Release of Diclofenac Sodium from The Mg-Al Layered Double Hydroxide Nanocomposites Synthesized Using PVP- SDS Soft Template

Samanmali, B. L. C.; Wimalasiri, A. K. D. V. K.; De Silva, R. M.; De Silva, K. M. N. (2022)

Controlled drug delivery systems have gained great attention in the pharmaceutical industry. The objectives of this research were to synthesize Mg-Al layered double hydroxide (LDH) nanocarriers using sodium dodecyl sulphate ...
Multifunctional HAP nanocomposites for antimicrobial activity

Fernando, M. Shanika; Wimalasiri, A. K. D. V. K.; Gayashan, M. K.; De Silva, R. M.; De Silva, K. M. N.; Dissanayake, D. P. (University of Colombo, 2020)

Contamination of water bodies by chemical and biological pollutants has resulted in shortage of clean and safe drinking water all over the world. Hydroxyapatite based nanocomposites have been identified as promising ...
Silica Based Superhydrophobic Nanocoatings for Natural Rubber Surfaces

Wimalasiri, V. K.; Weerathunga, H. U.; Kottegoda, N.; Karunaratne, V. (Hindawi, 2017-08-08)

Silica based nonfluorinated superhydrophobic coatings for natural rubber surfaces have been developed. The coating was synthesized using nanosilica dispersion and a polychloroprene type binder as a compatibilizer. This ...
Association of testosterone, inflammation with the severity of first acute ST-elevation myocardial infarction

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Elsevier, 2017-03)

Men with ischemic heart disease (IHD) are found to have low serum testosterone concentration and it is associated with chronic vascular and systemic inflammation. However, the findings are conflicting and warrant further ...
Association between anthropometric parameters and testosterone deficiency in men

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Sri Lanka Journal of Diabetes, 2014-08)

Objectives: Obesity and anthropometric measures are related to the testosterone concentration in men, although debate remains as to which anthropometric parameters are most important. Fat mass or adiposity is an important ...
Cardiovascular risk factors, socioeconomic determinants and angiographic severity of coronary artery disease in patients awaiting coronary artery bypass graft in a provincial hospital Sri Lanka

Wickramatilake, C. M.; Withanawasam, B. P. S.; Mohideen, M. R. (Galle Medical Association, 2015-01-11)

Introduction: The age-standardized death rate of coronary heart disease has shown a downward trend in many developed countries while an upward trend has been seen in developing countries with demographic changes, urbanization, ...
High-sensitivity C-reactive protein in Sri Lankan males with coronary artery disease

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Ibn Sina Trust, 2016-04-11)

Objectives: Evidence suggests that inflammation and dyslipideamia play a key role in the pathogenesis of coronary artery disease (CAD). High sensitivity C-reactive protein (hsCRP) is a sensitive marker of inflammation. We ...
Predictability of adverse clinical events following ST-elevation myocardial infarction by risk assessment tools

Wickramatilake, C. M.; Mohideen, M. R.; Pathirana, C. (Galle Medical Association, 2016-05-03)

Background: Killip classes, TIMI and GRACE scores are simple validated clinical risk scores used in risk stratification in acute coronary syndrome including ST-elevation myocardial infarction (STEMI). Objectives: Our ...
Novel risk factors for coronary artery disease – role of testosterone and high-sensitivity CRP in Sri Lankan males

Wickramatilake, C. M. (Ceylon College of Physicians, 2017-06-16)

Coronary artery disease (CAD) is multi-factorial in origin and develops as a result of both genetic and environmental factors. Traditional risk factors (generally smoking, hypertension, raised lipids, and diabetes mellitus) ...

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