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Department of Pathology: Recent submissions

Now showing items 21-40 of 121

Hepatoprotective Effect of Epaltes Divaricata Extract on Carbon Tetrachloride Induced Hepatotoxicity in Mice

Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B.; Pathirana, C. (Indian Journal of Medical Research, 2004-07)

Background & objectives: Epaltes divaricata is widely used in Sri Lanka as an Ayurvedic medicine. In the present study the hepatoprotective and antioxidative effects of an aqueous extract of E. divaricata plant (Family-Compositae) ...
Solitary Rectal Ulcer Syndrome (SRUS) Masquerading as a Carcinomatous Stricture

Lokuhetty, M.D.S.; De Silva, M.V.C.; Mudduwa, L.K.B. (Ceylon Medical Journal, 1999-01)
Toxicological Investigation of Spondias Pinnata (Linn. F.) Kurz. (Family: anacardiaceae) Bark Extract in Wistar Rats

Attanayake, A.P.; Mudduwa, L.K.B.; Jayatilaka, K.A.P.W.; Pathirana, C. (TIFAC CORE in Green Pharmacy, 2015-03-17)

Spondias pinnata (Linn. F.) Kurz. (Family: Anacardiaceae) is widely used in Sri Lankan traditional medicine for the treatment of diabetes mellitus. Aims: The aim was to investigate acute and subchronic toxicity of the ...
Epaltes Divaricata in Paracetamol Poisoning: a Biochemical and Histopathological Investigation

Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Galle Medical Association, 2015-07-15)

Introduction and Objective: In the practice of traditional ayurvedic medicine in Sri Lanka, a number of herbs have been recognized for their potential benefits in the treatment of liver disorders. This study was conducted ...
Association Between Age at Presentation and Pathological Features of Breast Cancer and its Effect on Survival; a Comparative Study done in Sri Lanka

Peiris, H.; Mudduwa, L.K.B.; Thalagala, N.; Jayatilaka, K.A.P.W. (International Institute for Primary Health Care, 2015-08)

Objective: The young age at presentation of breast can- cer (BC) is an independent prognostic factor of poor survival. Therefore the aim of this study was to deter- mine the association between age at presentation and ...
An Unusual Case of Mediastinal Malignant Melanoma with a Cardiac Metastasis

Lakmali, M.G.N.; Mudduwa, L.K.B.; Fernando, L.B.M.; Mahinda, H.A. (College of Forensic Pathologists of Sri Lanka, 2015-12-15)

Introduction Mediastinal tumours are often seen in patients aged 30–50 years. Most of them are neurogenic tumours and thymomas. Others include lymphomas, phaeochromocytomas, melanomas, germ cell tumours and thyroid and ...
Toxicological Evaluation of Five Sri Lankan Medicinal Plants: a Biochemical, Haematological and Histopathological Assessment

Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B.; Pathirana, C. (Innovare Academic Sciences, 2016-10-01)

Asteracantha longifolia, Asparagus falcatus, Vetiveria zizanioides, Coriandrum sativum and Epaltes divaricate have proven hepatoprotective and antioxidative effects against carbon tetrachloride and paracetamol induced ...
Modulatory Potential of Coriandrum Sativum on Experimentally Induced Hepatic Injury in ICR Mice: a Biochemical and Histopathological Investigation

Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B.; Pathirana, C. (Dr. Yashwant Research Labs Pvt. Ltd., 2016-10)

Ayurvedic medical practitioners in Sri Lanka use several locally available medicinal plants either as single drugs or in combination with other plants in the treatment of liver diseases. Corriandrum sativum, a glabrous ...
Do Breast Cancer Risk Factors Affect the Survival of Breast Cancer Patients in Southern Sri Lanka?

Peiris, H.H.; Mudduwa, L.K.B.; Thalagala, N.I.; Jayatilaka, K.A.P.W. (Asian Pacific Journal of Cancer Prevention, 2017-01)

Background: Breast cancer continues to be a major cause of morbidity among women in Sri Lanka. Possible effects of etiological risk factors on breast cancer specific survival (BCSS) of the disease is not clear. This ...
KIBRA Attains Oncogenic Activity by Repressing RASSF1A

Arivazhagan, A.L.; Surabhi, R.P.; Kanakarajan, A.; Sundaram, S.; Pitani, R.S.; Mudduwa, L.K.B.; Kremerskothen, J.; Venkatraman, G.; Rayala, S.K. (Springer, 2017-08-08)

Background: KIBRA—initially identified as a neuronal associated protein is now shown to be functionally associated with other tissue types as well. KIBRA interacts with dyenin light chain 1 and this interaction is ...
Ameliorative Effects of Asparagus Falcatus L and Vetiveria Zizanioides (L) Nash on Carbon Tetrachloride Induced Oxidative Stress in Mice

Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B.; Pathirana, C. (National Institute of Science Communication and Policy Research, 2017-07)

The hepatoprotective and antioxidative effects of two aqueous plant extracts, Asparagus falcatus and Vetiveria zizanioides, were determined against carbon tetrachloride (CCl4) induced oxidative stress in mice. Hepatotoxicity ...
Dose Response Effect of Nauclea Orientalis Bark Extract Against Doxorubicin Induced Cardiotoxicity in Wistar Rats

Sandamali, J.A.N.; Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Faculty of Medicine, University of Ruhuna, 2017-10)
Corrigendum to “Gmelina Arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats”

Attanayake, A.P.; Jayatilaka, K.A.P.W.; Pathirana, C.; Mudduwa, L.K.B. (Hindawi, 2018-11-05)

In the article titled “Gmelina arborea Roxb. (Family: Verbe- naceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats” [1], the following statement should be added as the second paragraph under ...
Animal Models of Chronic Kidney Disease: screening Tool to Investigate Nephroprotective Effects of Natural Products

Amarasiri, S.S.; Attanayake, A.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (IP Innovative Publication Pvt. Ltd, 2018-11)

Animals are used as experimental models to reproduce human diseases. To date, various animal models have been successfully developed by numerous methods to simulate human diseases including chronic kidney disease (CKD). ...
Tracing the Progress of Pathology in Sri Lanka – Part II: Undergraduate and Postgraduate Teaching in Pathology

Hewavisenthi, J.; Mudduwa, L.K.B. (College of Pathologists of Sri Lanka, 2019-12-30)
Cardioprotective Potential of Murraya koenigii (L.) Spreng. Leaf Extract Against Doxorubicin-Induced Cardiotoxicity in Rats

Sewwandi, J.A.N.; Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Hindawi, 2020-03-16)

Dose-dependent cardiotoxicity of doxorubicin may lead to irreversible congestive heart failure. Although multiple mechanisms are involved, generation of free radicals is the most commonly postulated mechanism. Therefore, ...
Quality Assurance in Immunohistochemistry for Better Patient Care

Mudduwa, L.K.B. (College of Pathologists of Sri Lanka, 2020-01-30)
Identifying Thyroid Follicular Proliferations that Need Lobectomy; value of the Bethesda Category 4

Kankanamge, A.; Liyanage, T.G.; Mudduwa, L.K.B. (Galle Medical Association, 2021-08-14)

Introduction: Thyroid follicular proliferations (TFPs) identified on fine needle aspiration cytology can be either follicular lesions of undetermined significance; Bethesda category 3 or follicular neoplasms and lesions ...
Toxicity Assessment of a Novel Polyherbal Mixture of 28-day Repeated Dose; a Trial Using Wistar Rats

Amarasiri, S.S.; Attanayake, A.P.; Mudduwa, L.K.B.; Jayatilaka, K.A.P.W. (University of Ruhuna Sri Lanka, 2022-02)
A Comparison of Cytology and Radiological Score with Histology in Patients with Breast Lumps: what Guides the Clinicians Best?

Thilini, H.G.D.; Perera, A.; Mudduwa, L.K.B. (College of Pathologists of Sri Lanka, 2022-03-31)

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