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Browsing Department of Pharmacology by Title

Now showing items 1-20 of 27

Adherence to the current guidelines in the management of paraquat poisoning

Jayasinghe, S.S.; Fernando, A. (Galle Medical Association, 2013-11-01)

Background: Self-poisoning with paraquat (PQ) is a major health problem with 60 -70% fatality. Fuller’s earth is the mainstay of therapy as other treatment modalities are controversial. Current management guidelines of ...
Adherence to the National Guidelines on the Management of Organophosphorus Poisoning

Jayasinghe, S.S.; Fernando, A.S. (Galle Medical Association, 2012-05-29)

Background: The National Guidelines on the Management of Organophosphorus (OP) poisoning include resuscitation, gastric lavage, administration of atropine and pralidoxime. Atropine should be commenced in the presence of ...
Administration of paracetamol to children; do parents adhere to recommendations?

Wanni Arachchi, T. I.; Gamage, M. W. K.; Jayasinghe, S. S. (Galle Medical Association, 2018-12-31)

Introduction: Fever is a common health problem in childhood. Parents often administer paracetamol to children without consulting a doctor since it is a widely available over the counter drug. The aim of this study was to ...
Arsenic and human health effects: A review

Jayasingh, Sudheera Sammanthi; Chandanaa, Ediriweera P.S.; Jayasumanac, Channa; De Silvaa, P. Mangala C.S.; Abdul, Khaja Shameem Mohammed (Elsevier, 2015-11-01)

Arsenic (As) is ubiquitous in nature and humans being exposed to arsenic via atmospheric air, ground water and food sources are certain. Major sources of arsenic contamination could be either through geological or via ...
Atropine therapy in acute anticholinesterase (Organophosphorus/carbamate) poisoning; adherence to current guidelines

Jayasinghe, S.S.; Fernando, A.; Pathirana, K.D.; Gunasinghe, K. Kishanthi (Galle Medical Association, 2009-10-08)

Purpose: Atropine is a life saving drug in acute anticholinesterase poisoning. Proper atropinization is associated with better clinical outcome. Hence we aimed to look at the adherence to existing guidelines on atropine ...
Autonomic Function following Acute Organophosphorus Poisoning: A Cohort Study

Jayasinghe, Sudheera S.; Pathirana, Kithsiri D. (Plos One, 2012-05-24)

Autonomic dysfunction after chronic low level exposure to organophosphorus (OP) pesticides has been consistently reported in the literature, but not following a single acute overdose. In order to study autonomic function ...
Correlation between BMI and insulin resistance in type 2 diabetes mellitus patients on pioglitazone treatment

Hettihewa, Lukshmy M; Dharmasira, Lalith P; Ariyaratne, Chamil D; Jayasinghe, Sudheera S; Weerarathna, Thilak P; Kotapola, Imendra G (Galle Medical Association, 2009-09-25)

doi: 10.4038/gmj.v12i1.1080 Galle Medical Journal Vol.12(1) 2007 18-24
Correlation between BMI and insulin resistance in type 2 diabetes mellitus patients on pioglitazone treatment

Hettihewa, Lukshmy M; Dharmasira, Lalith P; Ariyaratne, Chamil D; Jayasinghe, Sudheera S; Weerarathna, Thilak P; Kotapola, Imendra G (Galle Medical Association, 2009-09-25)

doi: 10.4038/gmj.v12i1.1080 Galle Medical Journal Vol.12(1) 2007 18-24
Correlation between changes of blood pressure with insulin resistance in type 2 diabetes mellitus with 4 weeks of pioglitazone therapy

Hettihewa, L M; Jayasinghe, S S; Imendra, K G; Weerarathna, T P (Springer, 2008-01)

Objective: To examine effects of pioglitazone (PIO) on systolic, diastolic, pulse and mean blood pressures (SBP, DBP, PP and MP, respectively) in type 2 diabetes mellitus (T2DM). Materials and methods: One hundred and ...
Effects of Acute Organophosphorus Poisoning on Function of Peripheral Nerves: A Cohort Study

Jayasinghe, Sudheera S.; Pathirana, Kithsiri D.; Buckley, Nick A. (Plos One, 2012-11-20)

Background: Following acute organophosphorus (OP) poisoning patients complain of numbness without objective sensory abnormalities or other features of OP induced delayed polyneuropathy. The aim of this study was to measure ...
Effects of Deliberate Ingestion of Organophosphate or Paraquat on Brain Stem Auditory-Evoked Potentials

Jayasinghe, Sudheera Sammanthi; Pathirana, Kithsiri Dedduwa (Springer, 2011-08-11)

Organophosphate (OP) and paraquat (PQ) ingestion is a serious health problem. A common pathology behind OP or PQ poisoning is the generation of reactive oxygen species (ROS) which is known to cause ototoxicity. The aim of ...
Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation

Hettihewa, Lukshmy Menik; Jayasinghe, Sudheera Sammanthi; Weerarathna, Thilak Priyantha; Gunasekara, Sudari Wijewickrama; Palangasinghe, Shalika; Kotapola, Imendra (OJHAS, 2005-05-10)

We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients. IR was assessed by fasting insulin test ...
Hearing impairment in children following bacterial meningitis; assessed with brainstem auditory evoked response (BSAER)

Jayasinghe, S.S.; Pathirana, K.D.; Vimalasena, G.T.H.I.P.; Taranga, D. (Galle Medical Association, 2012-05-29)

Background: Bacterial meningitis is one of the most serious infections occurring in children. Sensorineural hearing loss is the commonest complication of bacterial meningitis. Materials and Methods: We aimed to assess ...
Lipid abnormalities in type 2 diabetes mellitus patients in Sri Lanka

Hettihewa, Lukshmy Menik; Gunasekera, Sudari Wijewickrama; Jayasinghe, Sudheera Sammanthi; Palangasinghe, Shalika; Weerarathna, Thilak Priyantha; Kotapola, Imendra (Galle Medical Association, 2009-09-25)

Background & Objective: Previous studies suggest that the prevalence of dyslipidaemia in type 2 diabetes is high with respect to the general population. But data related to the prevalence of dyslipidaemia in ...
Neurotoxic effects of paraquat

Jayasinghe, S.S.; Seneviratne, S.A. (Galle Medical Association, 2016-10-15)

Paraquat (1, 1’ - dimethyl - 4, 4 - dipyridyl) is a bipyridyl compound. It was first marketed in 1962 as a broad-spectrum, non-selective and contact herbicide after having been described first byWeidel and Rosso in 1882. ...
Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka

Abdul, K.S.M.; De Silva, P. Mangala C.S.; Ekanayake, E.M.D.V.; Thakshila, W.A.K.G.; Gunarathna, S.D.; Gunasekara, T.D.K.S.C.; Jayasinghe, S.S.; Asanthi, H.B.; Chandana, E.P.S.; Chaminda, G.G.T.; Siribaddana, S.H.; Jayasundara, Nishad (MDPI, 2021-03-22)

Extensive use of herbicides is common among rural agricultural workers in Sri Lanka. Recent studies have postulated their role in the development of chronic kidney disease of unknown etiology (CKDu). Paraquat and glyphosate ...
Prevalence of CKD of Unknown Etiology and its Potential Risk Factors in a Rural Population in Sri Lanka

Wijewickrama, Eranga S.; GayaniThakshila, W.A.; Ekanayake, E.M. Dilini; Gunasekara, T.D.K. Sameera; Chandana, E.P.S.; Jayasinghe, Sudheera S.; Ruwanpathirana, Thilanga; Jayasinghe, Saroj; De Silva, M.C.S. (Elsevier, 2022-08-03)

Chronic kidney disease of unknown etiology (CKDu) is an emerging form of CKD that predominantly affects working-age adults belonging to agricultural communities living in discrete geographic areas. Disease hotspots have ...
Psychological distress among patients with organophosphorus or paraquat poisoning

Jayasinghe, S.S. (Galle Medical Association, 2011-10-30)

Introduction: Recognition of psychological distress following intentional self poisoning is important. The most widely used screening test for psychological distress is the Goldberg's General Health Questionnaire (GHQ). ...
Remission of diabetes mellitus after treatment with pioglitazone

Jayasinghe, S. S.; Hettihewa, L. M.; Gunasekara, S. W.; Palangasinghe, S.; Imendra, K. G.; Weerarathna, T. P. (Galle Medical Association, 2009-09-28)

Type 2 diabetes is a complex disease that involves insulin secretion abnormalities and defects in the action of insulin on its target tissues. This chronic metabolic disorder is associated with high mortality and ...
Short Research Communication: Predicting osteopathy among patients with thalassaemia major using selected clinical and biochemical information

Jayasinghe, S.S.; Lekamwasam, S.; De Silva, D.C.L.; Subasinghe, L.; Purasinghe, N. (Galle Medical Association, 2012-11-13)

Objectives: This study assessed the prevalence and surrogate makers of osteopathy among patients with thalassemia major. Methods: Bone mineral densities (BMDs) were measured by dual-energy x-ray absorptiometry of the ...

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