Browsing Department of Medical Laboratory Science by Author "Sandamali, J.A.N."

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Anthracycline-Induced Cardiotoxicity in Breast Cancer Patients from Southern Sri Lanka: An Echocardiographic Analysis

Sandamali, J.A.N.; Hewawasam, R.P.; Fernando, M.A.C.S.S.; Jayatilaka, K.A.P.W.; Madurawe, R.D.; Sathananthan, P.P.; Ekanayake, U.; Horadugoda, J. (Hindawi, 2020-11-16)

Anthracycline-induced cardiotoxicity has never been investigated in Sri Lanka. Therefore, this study was conducted to determine the prevalence of anthracycline-induced cardiotoxicity in breast cancer patients using ...
Cardioprotective potential of Murraya koenigii (L.) Spreng. leaf extract against doxorubicin-induced cardiotoxicity in rats

Sandamali, J.A.N.; Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Hindawi, 2020-03-16)

Dose-dependent cardiotoxicity of doxorubicin may lead to irreversible congestive heart failure. Although multiple mechanisms are involved, generation of free radicals is the most commonly postulated mechanism. +erefore, ...
Cinnamomum zeylanicum Blume (Ceylon cinnamon) bark extract attenuates doxorubicin induced cardiotoxicity in Wistar rats

Sandamali, J.A.N.; Hewawasam, R.P.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Elsevier, 2021-06-20)

Anti-tumour efficacy of doxorubicin is hindered by the cumulative dose-dependent cardiotoxicity induced by reactive oxygen species during its metabolism. As Cinnamomum zeylanicum has proven antioxidant potential, objective ...

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