Browsing Department of Medical Laboratory Science by Author "Ye, Zhengmao"

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Generation of molecular-targeting helix-loop-helix peptides for inhibition of the interaction between cytotoxic T-lymphocyte-associated protein 4 and B7 in the dog

Ramanayake, R.M.T.M.; Fujiwara, Daisuke; Michigami, Masataka; Watanabe, Shunichi; Ye, Zhengmao; Ueda, Atsuko; Kanegi, Ryoji; Hatoya, Shingo; Fujii, Ikuo; Sugiura, Kikuya (J-STAR, 2022-06-24)

Blocking the interaction between CD28 and B7 by cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a potent immune checkpoint that prevents damage to host tissues from excessive immune responses. However, it also ...
An Immune-Stimulatory Helix–Loop–Helix Peptide: Selective Inhibition of CTLA-4–B7 Interaction

Ramanayake, R.M.T.M.; Michigami, Masataka; Ye, Zhengmao; Uyeda, Atsuko; Inoue, Norimitsu; Sugiura, Kikuya; Fujii, Ikuo; Fujiwara, Daisuke (ACS publcations, 2019-12-16)

Molecular-targeting peptides and mini-proteins are promising alternatives to antibodies in a wide range of applications in bioscience and medicine. We have developed a helix−loop−helix (HLH) peptide as an alternative ...

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