Browsing Department of Medical Laboratory Science by Subject "HLH peptide"

Now showing items 1-2 of 2

An Immune-Stimulatory Helix–Loop–Helix Peptide: Selective Inhibition of CTLA-4–B7 Interaction

Ramanayake, R.M.T.M.; Michigami, Masataka; Ye, Zhengmao; Uyeda, Atsuko; Inoue, Norimitsu; Sugiura, Kikuya; Fujii, Ikuo; Fujiwara, Daisuke (ACS publcations, 2019-12-16)

Molecular-targeting peptides and mini-proteins are promising alternatives to antibodies in a wide range of applications in bioscience and medicine. We have developed a helix−loop−helix (HLH) peptide as an alternative ...
New Class of Drug Modalities: Directed Evolution of a De Novo Designed Helix–Loop–Helix Peptide to Bind VEGF for Tumor Growth Inhibition

Michigami, Masataka; Ramanayake, R.M.T.M.; Suzuki, Miho; Ishizako, Hirotsugu; Notsu, Kunpei; Sugiura, Kikuya; Fujii, Ikuo (ACS publcations, 2022-02-17)

As a small affinity molecule to serve as an alternative to antibodies, we have developed a conformationally constrained peptide with a de novo designed helix−loop−helix (HLH) scaffold. To evaluate its potential for ...

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