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Recent submissions

Department of Medical Laboratory Science: Recent submissions

Now showing items 101-111 of 111

Nephroprotective mechanisms of Ambrette (Abelmoschus moschatus Medik.) leaf extracts in adriamycin mediated acute kidney injury model of Wistar rats

Amarasiri, S.S.; Attanayake, A.P.; Mudduwa, L.K.B.; Jayatilaka, K.A.P.W. (Elsevier B.V., 2022-03-23)

Ethnopharmacological relevance: Ambrette (Abelmoschus moschatus Medik., Family: Malvaceae) is a common Ay urvedic herbal medicine used in the treatment of kidney-related diseases, in the forms of tea, medicated oil, ...
Nephroprotective activity of Vetiveria zizanioides (L.) Nash supplement in doxorubicin-induced nephrotoxicity model of Wistar rats. Journal of Food Biochemistry

Amarasiri, S.S.; Attanayake, A.P.; Arawwawala, L.D.A.M.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (WILEY-BlACKWELL, 2021-08-02)

The nephroprotective effect of standardized aqueous root extract of Vetiveria ziza nioides (L.) Nash (Family: Poaceae) was investigated in doxorubicin-induced (20 mg/ kg, ip) experimental nephrotoxicity model of Wistar ...
Standardized aqueous stem bark extract of Gmelina arborea Roxb. possesses nephroprotection against adriamycin-induced nephrotoxicity in Wistar rats

Amarasiri, S.S.; Attanayake, A.P.; Arawwawala, L.D.A.M.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Taylor & Francis, 2020-08-30)

Nephrotoxicity is a major limitation of adriamycin (ADR) chemotherapy. We hypothesized that adminis tration of standardized aqueous bark extract of Gmelina arborea Roxb. (GA) (Family; Verbenaceae), a traditional therapeutic ...
Protective effects of three selected standardized medicinal plant extracts used in Sri Lankan traditional medicine in adriamycin induced nephrotoxic Wistar rats

Amarasiri, S.S.; Attanayake, A.P.; Arawwawala, L.D.A.M.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Elsevier B.V., 2020-05-16)

Ethnopharmacological relevance: Abelmoschus moschatus Medik. (family: Malvaceae), Asparagus falcatus (family: Asparagaceae) and Barleria prionitis Linn. (family: Acanthaceae) have been used in the treatment of kidney diseases ...
Acute and 28-Day Repeated-Dose Oral Toxicity Assessment of Abelmoschus moschatus Medik. in Healthy Wistar Rats

Amarasiri, S.S.; Attanayake, A.P.; Arawwawala, L.D.A.M.; Jayatilaka, K.A.P.W.; Mudduwa, L.K.B. (Hindawi, 2020-06-19)

Abelmoschus moschatus Medik. (family: Malvaceae) has a long history of being used as a folk medicine in Sri Lanka. Despite the therapeutic use of this plant in traditional medicine, leaves of A. moschatus have not been ...
KIBRA; a novel biomarker predicting recurrence free survival of breast cancer patients receiving adjuvant therapy

Mudduwa, L.; Peiris, H.; Gunasekara, S.; Abeysiriwardhana, D.; Liyanage, N.; Rayala, S.K.; Liyanage, T. (BMC Cancer, 2018-05-24)

Background: This study was carried out to evaluate the prognostic value of KIBRA in breast cancer. Methods: This retrospective study included breast cancer patients who sought the services of the immunohistochemistry laboratory ...
Molecular classification of breast cancers using immunohistochemical surrogates; the Sri Lankan experience

Mudduwa, L.; Peiris, H.; Liyanage, L.; Abeysiriwardhana, D. (Journal of Diagnostic Pathology, 2019-06-30)

Background: Breast cancer diagnosis has evolved over the past decades. Today, it is vital to classify breast cancers according to genetic expression. Immunohistochemical surrogates have been identified as a cost-effective ...
Prognostic Significance of Low Claudin3 Expression in Luminal Breast Cancers

Mudduwa, L.; Peiris, H.; Gunasekara, S.; Abeysiriwardhana, D.; Liyanage, T. (Breast Cancer: Basic and Clinical Research, 2017-12-13)

Aim: To study the prognostic value of immunohistochemically detected low Claudin3 expression in breast cancers. Methods: This retrospective study included patients with breast cancer who were investigated at our unit from ...
The value of Nottingham grade in breast cancer re-visited in the Sri Lankan setting

Peiris, H.; Mudduwa, L.; Thalagala, N.; Jayatialake, K. (Malays J Pathol, 2017-08)

Objective: We aimed to assess the impact of Nottingham grade (NG) on breast cancer specific survival (BCSS) and recurrence free survival (RFS) of operable breast cancer (BC) patients presenting at different TNM stages ...
Trends in clinico-pathological and risk factor profile of breast cancer; 10-year experience at a single center in Sri Lanka

Mudduwa, L.; Peiris, H.; Liyanage, T.; Gunasekera, S.; Ranawaka, N. (Journal of Diagnostic Pathology, 2019)

Background The incidence of breast cancer in Sri Lanka is increasing on par with the rest of Asia. Lifestyle changes increasing the prevalence of risk factors of breast cancer among Asian women are claimed to be ...
Validity of St Gallen risk categories in prognostication of breast cancer patients in Southern Sri Lanka

Peiris, H.; Mudduwa, L.; Thalagala, N.; Jayatilake, K. (BMC Women's Health, 2018-01-31)

Background: Although, there are many developments in the field of management, breast cancer is still the commonest cause of cancer related deaths in women in Sri Lanka. This emphasizes the need for validation of treatment ...

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