Remission of diabetes mellitus after treatment with pioglitazone

Abstract

Type 2 diabetes is a complex disease that involves insulin secretion abnormalities and defects in the action of insulin on its target tissues. This chronic metabolic disorder is associated with high mortality and morbidity from long-term microvascular and macrovascular complications [1]. Thiazolidinediones (pioglitazone, rosiglitazone, and troglitazone) are synthetic peroxisomes proliferated receptor-ã agonists that decrease insulin resistance, may also have direct beneficial effects on pancreatic â cells [2]. Previous reports shows that decrease in fasting plasma insulin with pioglitazone associated with the improvement of insulin sensitivity [2]. Treatment with pioglitazone was associated with beneficial effects on blood lipid levels as well. Here we present a patient who got a remission of type 2 diabetes mellitus after 2 months of pioglitazone therapy (15 mg)