Citation:TY - JOUR T1 - Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions AU - Shang, Zhuo AU - Khalil, Zeinab AU - Li, Li AU - Salim, Angela A. AU - Quezada, Michelle AU - Kalansuriya, Pabasara AU - Capon, Robert J. Y1 - 2016/09/02 PY - 2016 DA - 2016/09/02 N1 - doi: 10.1021/acs.orglett.6b02099 DO - 10.1021/acs.orglett.6b02099 T2 - Organic Letters JF - Organic Letters JO - Org. Lett. SP - 4340 EP - 4343 VL - 18 IS - 17 PB - American Chemical Society SN - 1523-7060 M3 - doi: 10.1021/acs.orglett.6b02099 UR - https://doi.org/10.1021/acs.orglett.6b02099 ER -
Date:2016-08-18
Abstract:
Cultures of the estuarine fungus Penicillium roseopurpureum (CMB-MF038) yielded a diverse array of polyketides, many of which were related via a highly convergent biosynthetic pathway. In addition to revising and assigning structures, and documenting chemical and biological properties, pro-drug cytotoxic properties were attributed to roseopurpurins H (10) and I (11) on the basis of in situ reverse Michael addition to a cytotoxic Michael acceptor (12).
