Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions

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dc.contributor.author Shang, Zhuo
dc.contributor.author Khalil, Zeinab
dc.contributor.author Li, Li
dc.contributor.author Salim, Angela A.
dc.contributor.author Quezada, Michelle
dc.contributor.author Kalansuriya, P.
dc.contributor.author Capon, Robert J.
dc.date.accessioned 2023-09-13T05:13:07Z
dc.date.available 2023-09-13T05:13:07Z
dc.date.issued 2016-08-18
dc.identifier.citation TY - JOUR T1 - Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions AU - Shang, Zhuo AU - Khalil, Zeinab AU - Li, Li AU - Salim, Angela A. AU - Quezada, Michelle AU - Kalansuriya, Pabasara AU - Capon, Robert J. Y1 - 2016/09/02 PY - 2016 DA - 2016/09/02 N1 - doi: 10.1021/acs.orglett.6b02099 DO - 10.1021/acs.orglett.6b02099 T2 - Organic Letters JF - Organic Letters JO - Org. Lett. SP - 4340 EP - 4343 VL - 18 IS - 17 PB - American Chemical Society SN - 1523-7060 M3 - doi: 10.1021/acs.orglett.6b02099 UR - https://doi.org/10.1021/acs.orglett.6b02099 ER - en_US
dc.identifier.uri http://ir.lib.ruh.ac.lk/xmlui/handle/iruor/14621
dc.description.abstract Cultures of the estuarine fungus Penicillium roseopurpureum (CMB-MF038) yielded a diverse array of polyketides, many of which were related via a highly convergent biosynthetic pathway. In addition to revising and assigning structures, and documenting chemical and biological properties, pro-drug cytotoxic properties were attributed to roseopurpurins H (10) and I (11) on the basis of in situ reverse Michael addition to a cytotoxic Michael acceptor (12). en_US
dc.language.iso en en_US
dc.publisher ACS Publications en_US
dc.title Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions en_US
dc.type Article en_US


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